(Q27665898)

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Converting the Highly Amyloidogenic Human Calcitonin into a Powerful Fibril Inhibitor by Three-dimensional Structure Homology with a Non-amyloidogenic Analogue

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Converting the Highly Amyloidogenic Human Calcitonin into a Powerful Fibril Inhibitor by Three-dimensional Structure Homology with a Non-amyloidogenic Analogue (English)

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5

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Ehud Gazit

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author name string

Giuseppina Andreotti

1

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Rosa Maria Vitale

2

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Carmit Avidan-Shpalter

3

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Pietro Amodeo

4

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Andrea Motta

6

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language of work or name

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publication date

28 January 2011

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Journal of Biological Chemistry

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286

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4

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2707-18

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Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences

1 reference

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20 March 2017

Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

20 March 2017

Environment affects amino acid preference for secondary structure

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

20 March 2017

MOLMOL: a program for display and analysis of macromolecular structures

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

20 March 2017

Structural Determinants of Salmon Calcitonin Bioactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

20 March 2017

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Amino acid position-specific contributions to amyloid beta-protein oligomerization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Alpha-helix targeting reduces amyloid-beta peptide toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Amyloid beta protein: Abeta40 inhibits Abeta42 oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Disrupting beta-amyloid aggregation for Alzheimer disease treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Peptide-based inhibitors of amyloid assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Rationale for the potential use of calcitonin in osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Structure-immunogenicity relationships of therapeutic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Bioequivalence and the immunogenicity of biopharmaceuticals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

A possible role for pi-stacking in the self-assembly of amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Channel formation by salmon and human calcitonin in black lipid membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Conformational flexibility in calcitonin: the dynamic properties of human and salmon calcitonin in solution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

An autonomous folding unit mediates the assembly of two-stranded coiled coils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Determinants for calcitonin analog interaction with the calcitonin receptor N-terminus and transmembrane-loop regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

The structure and mechanism of formation of human calcitonin fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Homologous regulation of the calcitonin receptor in mouse osteoclast-like cells and human breast cancer T47D cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

An evaluation of antibodies and clinical resistance to salmon calcitonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Dynamic properties of salmon calcitonin bound to sodium dodecyl sulfate micelles: a restrained molecular dynamics study from NMR data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Calcitonin and calcium ionophores: cyclic AMP responses in cells of a human lymphoid line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

29 September 2017

Mutations enhance the aggregation propensity of the Alzheimer's A beta peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

2 June 2018

Multiple-pulse mixing sequences that selectively enhance chemical exchange or cross-relaxation peaks in high-resolution NMR spectra.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

2 June 2018

Neutralizing antibodies against calcitonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

2 June 2018

Calcitonin-induced anorexia in rats: a structure-activity study by intraventricular injections.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

2 June 2018

Modulating calcitonin fibrillogenesis: an antiparallel alpha-helical dimer inhibits fibrillation of salmon calcitonin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Amyloid fibril formation by pentapeptide and tetrapeptide fragments of human calcitonin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Prediction of aggregation-prone regions in structured proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Abeta40 inhibits amyloid deposition in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

A role for helical intermediates in amyloid formation by natively unfolded polypeptides?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Specific mutations alter fibrillation kinetics, fiber morphologies, and membrane interactions of pentapeptides derived from human calcitonin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Competition between intramolecular and intermolecular interactions in an amyloid-forming protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Prediction of amyloid fibril-forming proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Kinetic studies of amyloid beta-protein fibril assembly. Differential effects of alpha-helix stabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.182014

21 January 2018

Solution structure of human calcitonin in membrane-mimetic environment: the role of the amphipathic helix.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

27 November 2018

Comparative study of human and salmon calcitonin secondary structure in solutions with low dielectric constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3024767

27 November 2018

Abeta40 protects non-toxic Abeta42 monomer from aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced potency of human calcitonin when fibrillation is avoided

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Architecture and Polymorphism of Fibrillar Supramolecular Assemblies Produced by in Vitro Aggregation of Human Calcitonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of human calcitonin fibrillation by proton nuclear magnetic resonance spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Role for the C-Terminus of Calcitonin in Aggregation and Gel Formation: A Comparative Study of C-Terminal Fragments of Human and Salmon Calcitonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of G protein activation in the toxicity of amyloidogenic Abeta-(1-40), Abeta-(25-35), and bovine calcitonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theory and applications of the generalized Born solvation model in macromolecular simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Calcitonin on Bone Lesions in Chronic Dialysis Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcitonin induction of a persistent activated state of adenylate cyclase in human breast cancer cells (T 47D)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aromatic rings act as hydrogen bond acceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aromatic Interactions Are Not Required for Amyloid Fibril Formation by Islet Amyloid Polypeptide but Do Influence the Rate of Fibril Formation and Fibril Morphology†

1 reference

https://pubmed.ncbi.nlm.nih.gov/21078667

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.182014

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release_j5jppf4fhfepxlxaprxj5k64ua

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