(Q27666159)

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Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

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scholarly article

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Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41 (English)

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crystal structure

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1 reference

based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

inferred from title

Antonio Lanzavecchia

14

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Federica Sallusto

12

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Gabriella Scarlatti

object named as

Gabriella Scarlatti

11

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10

object named as

Lara Mainetti

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8

object named as

Gloria Agatic

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Fabrizia Vanzetta

7

object named as

Fabrizia Vanzetta

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author name string

Charles Sabin

1

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Davide Corti

2

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Victor Buzon

3

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Mike S Seaman

4

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David Lutje Hulsik

5

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Andreas Hinz

6

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Chiara Silacci

9

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Robin Weiss

13

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Winfried Weissenhorn

15

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publication date

18 November 2010

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6

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11

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e1001195

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copyright license

Creative Commons Attribution 4.0 International

18 November 2010

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April 2022 Public Data File from Crossref

copyright status

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Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions

1 reference

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20 March 2017

HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes

1 reference

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20 March 2017

Viral membrane fusion

1 reference

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20 March 2017

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

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20 March 2017

Short constrained peptides that inhibit HIV-1 entry

1 reference

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20 March 2017

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

1 reference

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20 March 2017

Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues

1 reference

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20 March 2017

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

1 reference

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20 March 2017

Atomic structure of the ectodomain from HIV-1 gp41

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20 March 2017

Core structure of gp41 from the HIV envelope glycoprotein

1 reference

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20 March 2017

Phasercrystallographic software

1 reference

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20 March 2017

Scaling and assessment of data quality

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

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20 March 2017

Automated protein model building combined with iterative structure refinement

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20 March 2017

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

1 reference

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20 March 2017

Determinants of human immunodeficiency virus type 1 resistance to gp41-derived inhibitory peptides.

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20 March 2017

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

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20 March 2017

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition

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20 March 2017

Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

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20 March 2017

Capture of an early fusion-active conformation of HIV-1 gp41

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20 March 2017

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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20 March 2017

Structure of a V3-containing HIV-1 gp120 core

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7 April 2017

Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

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7 April 2017

ElNemo: a normal mode web server for protein movement analysis and the generation of templates for molecular replacement

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7 April 2017

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

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7 April 2017

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

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7 April 2017

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

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29 September 2017

Rational antibody-based HIV-1 vaccine design: current approaches and future directions

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29 September 2017

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

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Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

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29 September 2017

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 [...]

1 reference

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29 September 2017

Peptides in the treatment of AIDS.

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29 September 2017

International network for comparison of HIV neutralization assays: the NeutNet report

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29 September 2017

Short communication: In vitro synergy between peptides or neutralizing antibodies targeting the N- and C-terminal heptad repeats of HIV Type 1 gp41.

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29 September 2017

Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice

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29 September 2017

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

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29 September 2017

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.

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29 September 2017

A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.

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29 September 2017

Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications

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29 September 2017

Virus membrane fusion

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29 September 2017

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

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29 September 2017

Increased efficacy of HIV-1 neutralization by antibodies at low CCR5 surface concentration.

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29 September 2017

Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.

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29 September 2017

A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

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29 September 2017

Class I and class II viral fusion protein structures reveal similar principles in membrane fusion

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29 September 2017

Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes

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Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes.

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29 September 2017

Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.

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29 September 2017

Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.

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29 September 2017

Protein design of an HIV-1 entry inhibitor

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29 September 2017

Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41

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29 September 2017

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

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29 September 2017

Co-receptors for HIV-1 entry

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29 September 2017

Design and characterization of an engineered gp41 protein from human immunodeficiency virus-1 as a tool for drug discovery

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2 June 2018

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

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21 January 2018

Antibodies purified from sera of HIV-1-infected patients by affinity on the heptad repeat region 1/heptad repeat region 2 complex of gp41 neutralize HIV-1 primary isolates

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21 January 2018

Mother-to-child transmission of human immunodeficiency virus type 1: correlation with neutralizing antibodies against primary isolates

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21 January 2018

Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion

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12 December 2020

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Rapid emergence of enfuvirtide resistance in HIV-1-infected patients: results of a clonal analysis

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12 December 2020

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Steric accessibility of the HIV-1 gp41 N-trimer region

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12 December 2020

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Identifiers

10.1371/JOURNAL.PPAT.1001195

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_6ohpa7h3ujgr5ipm2kuvc7seda

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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