(Q30843874)

English

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

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7 January 2020

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics (English)

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7 January 2020

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G. Marius Clore

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7 January 2020

Dennis R. Burton

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Dennis R Burton

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7 January 2020

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Josh D Nelson

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7 January 2020

Heather Kinkead

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7 January 2020

Florence M Brunel

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7 January 2020

Dan Leaman

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7 January 2020

Richard Jensen

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7 January 2020

John M Louis

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Toshiaki Maruyama

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Carole A Bewley

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7 January 2020

Katherine Bowdish

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7 January 2020

Philip E Dawson

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7 January 2020

Shana Frederickson

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7 January 2020

Rose G Mage

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7 January 2020

Douglas D Richman

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Michael B Zwick

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7 January 2020

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21 May 2008

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7 January 2020

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14

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7 January 2020

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7 January 2020

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7 January 2020

170-183

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7 January 2020

Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data

1 reference

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28 July 2018

HIV-1 neutralization: mechanisms and relevance to vaccine design

1 reference

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28 July 2018

Potent D-peptide inhibitors of HIV-1 entry

1 reference

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28 July 2018

A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.

1 reference

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28 July 2018

Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.

1 reference

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28 July 2018

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

1 reference

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28 July 2018

Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies

1 reference

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28 July 2018

Structural definition of a conserved neutralization epitope on HIV-1 gp120

1 reference

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28 July 2018

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

1 reference

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28 July 2018

Rational modifications of HIV-1 envelope glycoproteins for immunogen design

1 reference

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28 July 2018

Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy

1 reference

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28 July 2018

Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning

1 reference

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28 July 2018

Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state

1 reference

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28 July 2018

Role of neutralizing antibodies in protective immunity against HIV.

1 reference

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28 July 2018

Cryo-electron tomographic structure of an immunodeficiency virus envelope complex in situ

1 reference

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28 July 2018

Increased efficacy of HIV-1 neutralization by antibodies at low CCR5 surface concentration.

1 reference

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28 July 2018

Distribution and three-dimensional structure of AIDS virus envelope spikes

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28 July 2018

GP120: target for neutralizing HIV-1 antibodies

1 reference

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28 July 2018

Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.

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28 July 2018

Structure of a V3-containing HIV-1 gp120 core

1 reference

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28 July 2018

Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.

1 reference

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28 July 2018

A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

1 reference

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28 July 2018

Comparing antigenicity and immunogenicity of engineered gp120.

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28 July 2018

Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation.

1 reference

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28 July 2018

Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection

1 reference

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28 July 2018

Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies

1 reference

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28 July 2018

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

1 reference

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28 July 2018

Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV.

1 reference

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28 July 2018

Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralization

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28 July 2018

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28 July 2018

Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

1 reference

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28 July 2018

Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies

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28 July 2018

Human antibodies from immunized donors are protective against anthrax toxin in vivo

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28 July 2018

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28 July 2018

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

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28 July 2018

Medicine. The need for a global HIV vaccine enterprise

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28 July 2018

A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12.

1 reference

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28 July 2018

Covalent trimers of the internal N-terminal trimeric coiled-coil of gp41 and antibodies directed against them are potent inhibitors of HIV envelope-mediated cell fusion.

1 reference

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28 July 2018

Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display

1 reference

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28 July 2018

Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies

1 reference

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28 July 2018

Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

1 reference

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28 July 2018

A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.

1 reference

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28 July 2018

Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.

1 reference

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28 July 2018

Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region

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28 July 2018

Design and properties of N(CCG)-gp41, a chimeric gp41 molecule with nanomolar HIV fusion inhibitory activity

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28 July 2018

Protein design of an HIV-1 entry inhibitor

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28 July 2018

Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

1 reference

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28 July 2018

Generation and structural analysis of soluble oligomeric gp140 envelope proteins derived from neutralization-resistant and neutralization-susceptible primary HIV type 1 isolates

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28 July 2018

Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.

1 reference

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28 July 2018

Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41

1 reference

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28 July 2018

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket

1 reference

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28 July 2018

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

1 reference

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28 July 2018

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28 July 2018

A conformation-specific monoclonal antibody reacting with fusion-active gp41 from the human immunodeficiency virus type 1 envelope glycoprotein.

1 reference

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28 July 2018

Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41

1 reference

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28 July 2018

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

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28 July 2018

CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization

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28 July 2018

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

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28 July 2018

Atomic structure of the ectodomain from HIV-1 gp41

1 reference

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28 July 2018

Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein

1 reference

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28 July 2018

Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.

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28 July 2018

Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding

1 reference

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28 July 2018

Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

2 references

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28 July 2018

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 inhibition by a peptide

1 reference

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28 July 2018

Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

1 reference

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28 July 2018

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

1 reference

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28 July 2018

A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

1 reference

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28 July 2018

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

1 reference

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28 July 2018

Epitope exposure on functional, oligomeric HIV-1 gp41 molecules

1 reference

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28 July 2018

Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

28 July 2018

Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

28 July 2018

Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

28 July 2018

Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

A monoclonal Fab derived from a human nonimmune phage library reveals a new epitope on gp41 and neutralizes diverse human immunodeficiency virus type 1 strains.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Biophysical evidence of two docking sites of the carboxyl heptad repeat region within the amino heptad repeat region of gp41 of human immunodeficiency virus type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Kinetic dependence to HIV-1 entry inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

The production of cleaved, trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein vaccine antigens and infectious pseudoviruses using linear polyethylenimine as a transfection reagent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploring

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

V3: HIV's switch-hitter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Mechanisms of viral membrane fusion and its inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Expression and characterization of HIV type 1 envelope protein associated with a broadly reactive neutralizing antibody response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Core structure of gp41 from the HIV envelope glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Length distribution of CDRH3 in antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Anticardiolipin wet workshop report. Fifth International Symposium on antiphospholipid antibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Preparation and characterization of human HIV type 1 neutralizing reference sera

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493441

25 November 2018

Neutralizing as well as non-neutralizing polyclonal immunoglobulin (Ig)G from infected patients capture HIV-1 via antibodies directed against the principal immunodominant domain of gp41

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

Exposure of the membrane-proximal external region of HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

The hydrophobic pocket contributes to the structural stability of the N-terminal coiled coil of HIV gp41 but is not required for six-helix bundle formation

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

Steric accessibility of the HIV-1 gp41 N-trimer region

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin by antithrombin

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.04.005

7 January 2021

Identifiers

10.1016/J.VIROL.2008.04.005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499210%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

release_yuvsduyuwbasldmk565hfmqo6e

1 reference

https://api.fatcat.wiki/v0/release/yuvsduyuwbasldmk565hfmqo6e

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499210%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499210%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

ResearchGate publication ID

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