(Q27667495)

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Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

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Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex (English)

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protein structure

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Mikako Shirouzu

5

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Christina R Chow

object named as

Christina R Chow

4

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Mutsuko Kukimoto-Niino

object named as

Mutsuko Kukimoto-Niino

2

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Shigeyuki Yokoyama

object named as

Shigeyuki Yokoyama

8

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6

object named as

Takaho Terada

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Chiemi Mishima-Tsumagari

3

object named as

Chiemi Mishima-Tsumagari

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author name string

Nicole Hajicek

1

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Maulik Patel

7

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Tohru Kozasa

9

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language of work or name

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publication date

10 June 2011

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Journal of Biological Chemistry

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286

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23

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20625-36

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

1 reference

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Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton

1 reference

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20 March 2017

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

1 reference

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20 March 2017

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

1 reference

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20 March 2017

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF

1 reference

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20 March 2017

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Structure of the rgRGS domain of p115RhoGEF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding

1 reference

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20 March 2017

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Protein structure comparison by alignment of distance matrices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

20 March 2017

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115‐RhoGEF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Structure and function of regulator of G protein signaling homology domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Structural basis of function in heterotrimeric G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Regulation of RGS-RhoGEFs by Galpha12 and Galpha13 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Purification and characterization of the alpha subunit of G13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

29 September 2017

Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

2 June 2018

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121507

2 June 2018

Mechanisms for reversible regulation between G13 and Rho exchange factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.201392

21 January 2018

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.201392

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.201392

21 January 2018

Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/21507947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21507947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21507947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.201392

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