(Q27667848)

PHENIX: a comprehensive Python-based system for macromolecular structure solution

GOA release 2020-03-11

author

Eric Gouaux

series ordinal

2

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author name string

Ryan E Hibbs

series ordinal

1

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language of work or name

English

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publication date

2 June 2011

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published in

Nature

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volume

474

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page(s)

54-60

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issue

7349

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cites work

1 reference

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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

20 March 2017

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Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

20 March 2017

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X-ray structure of a prokaryotic pentameric ligand-gated ion channel

20 March 2017

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X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

20 March 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

20 March 2017

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

20 March 2017

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A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish

20 March 2017

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Phasercrystallographic software

20 March 2017

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The Buccaneer software for automated model building. 1. Tracing protein chains

20 March 2017

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Scaling and assessment of data quality

20 March 2017

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The integration of macromolecular diffraction data

20 March 2017

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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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Solvent content of protein crystals

20 March 2017

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

20 March 2017

1 reference

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

20 March 2017

1 reference

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Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

20 March 2017

1 reference

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PROMALS3D: a tool for multiple protein sequence and structure alignments

20 March 2017

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

7 April 2017

1 reference

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The structural basis of function in Cys-loop receptors.

7 April 2017

1 reference

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General anesthetic actions on GABA(A) receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Binding, activation and modulation of Cys-loop receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Robust indexing for automatic data collection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

A prokaryotic perspective on pentameric ligand-gated ion channel structure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

29 September 2017

1 reference

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Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins

29 September 2017

1 reference

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Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

29 September 2017

1 reference

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Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

29 September 2017

1 reference

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Ligand-gated ion channels: mechanisms underlying ion selectivity

29 September 2017

1 reference

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Codon optimization of Caenorhabditis elegans GluCl ion channel genes for mammalian cells dramatically improves expression levels.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Assembly and clustering of acetylcholine receptors containing GFP-tagged epsilon or gamma subunits: selective targeting to the neuromuscular junction in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Ivermectin, an unconventional agonist of the glycine receptor chloride channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Pairwise interactions between neuronal alpha(7) acetylcholine receptors and alpha-conotoxin PnIB.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Subunit mutations affect ethanol actions on GABA(A) receptors expressed in Xenopus oocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Mutagenesis of the GABA rho 1 receptor alters agonist affinity and channel gating

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The pore dimensions of gramicidin A.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The alpha-helix as an electric macro-dipole

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Picrotoxin blockade of invertebrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

An amino acid substitution in the pore region of a glutamate-gated chloride channel enables the coupling of ligand binding to channel gating.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Ivermectin: A Potent New Antiparasitic Agent

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Efficacy and tolerance of ivermectin in human onchocerciasis

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The Nano-tag, a streptavidin-binding peptide for the purification and detection of recombinant proteins

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The contribution of proline 250 (P-2') to pore diameter and ion selectivity in the human glycine receptor channel

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Activation of rat recombinant alpha(1)beta(2)gamma(2S) GABA(A) receptor by the insecticide ivermectin.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3160419

The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potential

27 November 2018

1 reference

12 December 2020

Structural basis for lipid modulation of nicotinic acetylcholine receptor function

1 reference

12 December 2020

Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter

1 reference

12 December 2020

Hydration of sodium, potassium, and chloride ions in solution and the concept of structure maker/breaker

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Identification of the alpha subunit half-cystine specifically labeled by an affinity reagent for the acetylcholine receptor binding site

1 reference

12 December 2020

Effects of agonists and antagonists on the reactivity of the binding site disulfide in acetylcholine receptor from Torpedo californica

1 reference

12 December 2020

Anion permeation in GABA- and glycine-gated channels of mammalian cultured hippocampal neurons

1 reference

12 December 2020

Automated diffraction image analysis and spot searching for high-throughput crystal screening

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE10139

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE10139

1 reference

Dimensions Publication ID

733267

1028827639

0 references

733267

1 reference

1 reference

1 reference