(Q27668096)

9

0 references

Hartmut Oschkinat

7

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Jörn Saupe

object named as

Jörn Saupe

1

0 references

Anne Diehl

object named as

Anne Diehl

6

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Jörg Rademann

object named as

Jörg Rademann

10

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author name string

Christian Schillinger

3

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Nestor Kamdem

4

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Silke Radetzki

5

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Gerd Krause

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

8

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publication date

1 August 2011

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published in

ChemMedChem

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volume

6

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issue

8

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page(s)

1411-22

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cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Origin of PDZ (DHR, GLGF) domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Druggability indices for protein targets derived from NMR-based screening data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Targeting protein-protein interactions for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

21 January 2018

1 reference

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PDZ domain proteins of synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Organization of signaling complexes by PDZ-domain scaffold proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Identification of proteins interacting with the rat somatostatin receptor subtype 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

An architectural framework that may lie at the core of the postsynaptic density

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Regulation of dendritic spine morphology and synaptic function by Shank and Homer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

21 January 2018

1 reference

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A synaptic trek to autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Current strategies for the development of peptide-based anti-cancer therapeutics

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201100094

Trojan peptides: the penetratin system for intracellular delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.201100094

SMART: a web-based tool for the study of genetically mobile domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Protein production by auto-induction in high density shaking cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

PDZ domain binding selectivity is optimized across the mouse proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Searching protein structure databases with DaliLite v.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Facilities and methods for the high-throughput crystal structural analysis of human proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Refinement of macromolecular structures by the maximum-likelihood method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094

Coot: model-building tools for molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201100094