(Q27671534)

3

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author name string

Susana Gonçalves

1

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Stephen P Miller

2

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Anthony M Dean

Structure of a highly NADP+-specific isocitrate dehydrogenase

4

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language of work or name

English

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publication date

11 September 2012

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published in

Biochemistry

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volume

51

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issue

36

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page(s)

7098-115

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cites work

1 reference

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Structural Basis of the Substrate Specificity of Bifunctional Isocitrate Dehydrogenase Kinase/Phosphatase

20 March 2017

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Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H

20 March 2017

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Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions

20 March 2017

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Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase

20 March 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

20 March 2017

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Structural studies ofSaccharomyces cerevesiaemitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction

20 March 2017

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Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: hydride transfer and co-factor specificity

20 March 2017

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Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism

20 March 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

20 March 2017

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Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase

20 March 2017

1 reference

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Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP

20 March 2017

1 reference

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Sites of binding and orientation in a four-location model for protein stereospecificity

20 March 2017

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A new model for protein stereospecificity

20 March 2017

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Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase

20 March 2017

1 reference

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Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs

20 March 2017

1 reference

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Structure of 3-isopropylmalate dehydrogenase in complex with 3-isopropylmalate at 2.0 A resolution: the role of Glu88 in the unique substrate-recognition mechanism

20 March 2017

1 reference

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Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting

20 March 2017

1 reference

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Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences

20 March 2017

1 reference

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Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant

20 March 2017

1 reference

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Structure of isocitrate dehydrogenase with alpha-ketoglutarate at 2.7-A resolution: conformational changes induced by decarboxylation of isocitrate

20 March 2017

1 reference

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Structure of 3-isopropylmalate dehydrogenase in complex with NAD+: ligand-induced loop closing and mechanism for cofactor specificity

20 March 2017

1 reference

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Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase

20 March 2017

1 reference

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Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase

20 March 2017

1 reference

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Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme

20 March 2017

1 reference

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Regulation of an enzyme by phosphorylation at the active site

20 March 2017

1 reference

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Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes

20 March 2017

1 reference

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

20 March 2017

1 reference

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Overview of the CCP4 suite and current developments

20 March 2017

1 reference

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Features and development of Coot

20 March 2017

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Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

20 March 2017

1 reference

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PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

20 March 2017

1 reference

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Likelihood-enhanced fast rotation functions

20 March 2017

1 reference

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A graphical user interface to the CCP4 program suite

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

ARP/wARP and molecular replacement

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Improved R-factors for diffraction data analysis in macromolecular crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Solvent content of protein crystals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Systematic analysis of domain motions in proteins from conformational change: new results on citrate synthase and T4 lysozyme

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

JLigand: a graphical tool for the CCP4 template-restraint library

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Direct demonstration of an adaptive constraint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Control of isocitrate dehydrogenase catalytic activity by protein phosphorylation in Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Second-site suppression of regulatory phosphorylation in Escherichia coli isocitrate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Synthesis, kinetics, and structural studies of a photolabile caged isocitrate: a catalytic trigger for isocitrate dehydrogenase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Tartrate dehydrogenase, a new member of the family of metal-dependent decarboxylating R-hydroxyacid dehydrogenases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Characterization and distribution of tartrate utilization genes in the grapevine pathogen Agrobacterium vitis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

The mechanisms of reductive carboxylation reactions. Carbon dioxide or bicarbonate as substrate of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase and malic enzyme

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

PDBe: Protein Data Bank in Europe

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

A lysine-tyrosine pair carries out acid-base chemistry in the metal ion-dependent pyridine dinucleotide-linked beta-hydroxyacid oxidative decarboxylases

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Critical Role of Lys212 and Tyr140 in Porcine NADP-dependent Isocitrate Dehydrogenase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Structure of isocitrate dehydrogenase with isocitrate, nicotinamide adenine dinucleotide phosphate, and calcium at 2.5-A resolution: a pseudo-Michaelis ternary complex

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Kinetic mechanism of Escherichia coli isocitrate dehydrogenase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

pH variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460525

Combining Laue diffraction and molecular dynamics to study enzyme intermediates

27 November 2018

1 reference

12 December 2020

Evaluation by site-directed mutagenesis of aspartic acid residues in the metal site of pig heart NADP-dependent isocitrate dehydrogenase

1 reference

12 December 2020

THE MECHANISM OF ACTION OF 6-PHOSPHOGLUCONATE DEHYDROGENASE

1 reference

12 December 2020

Ionization of isocitrate bound to pig heart NADP+-dependent isocitrate dehydrogenase: 13C NMR study of substrate binding

1 reference

12 December 2020

[The enzymatic properties of isocitric dehydrogenase]

1 reference

12 December 2020

Mutational analysis of the catalytic residues lysine 230 and tyrosine 160 in the NADP(+)-dependent isocitrate dehydrogenase from Escherichia coli

1 reference

12 December 2020

release_ydjamsmnn5ev7mcyf2wnmak2ri

Identifiers

DOI

10.1021/BI300483W

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ydjamsmnn5ev7mcyf2wnmak2ri

24 November 2022