(Q27674627)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

protein localization to site of double-strand break

15 February 2020

main subject

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1990166

histone phosphorylation

1 reference

Gene Ontology release 2020-05-02

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

John A. Tainer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

author name string

Davide Moiani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Aryandi Kertokalio

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Claire Wyman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Paul Russell

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

language of work or name

English

0 references

publication date

17 October 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

published in

Nucleic Acids Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

issue

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

11435-11449

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 3.0 Unported

15 February 2020

copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3526295/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3526295/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

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Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

20 March 2017

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Crystal structure of human Mre11: understanding tumorigenic mutations

20 March 2017

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ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex

20 March 2017

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Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

20 March 2017

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The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair

20 March 2017

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ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

20 March 2017

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

20 March 2017

1 reference

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Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair

20 March 2017

1 reference

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A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage

20 March 2017

1 reference

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Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

20 March 2017

1 reference

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

20 March 2017

1 reference

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Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Megabase chromatin domains involved in DNA double-strand breaks in vivo

20 March 2017

1 reference

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

20 March 2017

1 reference

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Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Histone H2A variants H2AX and H2AZ

20 March 2017

1 reference

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Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

ATR: an essential regulator of genome integrity

20 March 2017

1 reference

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

7 April 2017

1 reference

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Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

7 April 2017

1 reference

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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

7 April 2017

1 reference

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Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.

29 September 2017

1 reference

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Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.

29 September 2017

1 reference

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Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

29 September 2017

1 reference

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Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50

29 September 2017

1 reference

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The MRE11 complex: starting from the ends.

29 September 2017

1 reference

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DNA end resection--unraveling the tail

29 September 2017

1 reference

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Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Regulation of DNA strand exchange in homologous recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

DNA double-strand break repair: all's well that ends well

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Basic methods for fission yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Competition between the Rad50 complex and the Ku heterodimer reveals a role for Exo1 in processing double-strand breaks but not telomeres

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Two modes of survival of fission yeast without telomerase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Mre11-Rad50-Xrs2 and Sae2 promote 5' strand resection of DNA double-strand breaks

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Definition of the interaction domain for cytochrome c on cytochrome c oxidase. III. Prediction of the docked complex by a complete, systematic search

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3526295

Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma

2 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS954

Meiotic DNA breaks associated with recombination in S. pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS954

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS954

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS954

Homo-oligomerization is the essential function of the tandem BRCT domains in the checkpoint protein Crb2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKS954

Protein docking using continuum electrostatics and geometric fit

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23080121

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKS954

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

release_n66mf33xizfpng2gvfvxewnpo4

15 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/n66mf33xizfpng2gvfvxewnpo4

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

PubMed publication ID

23080121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23080121%20AND%20SRC:MED&resulttype=core&format=json