(Q27675368)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

main subject

X-ray crystallography

0 references

author

Martin Weik

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Claudio Ronco

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Ludovic Jean

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Pierre-Yves Renard

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Eugénie Carletti

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Jacques-Philippe Colletier

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Florian Nachon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

publication date

4 November 2011

1 reference

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15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

400-405

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22052791%20AND%20SRC:MED&resulttype=core&format=json

Alzheimer disease: progress or profit?

15 January 2020

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Novel huprine derivatives with inhibitory activity toward β-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates

21 January 2018

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Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

21 January 2018

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New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

21 January 2018

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Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.

21 January 2018

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Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease

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Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

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3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

21 January 2018

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Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex

21 January 2018

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Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

21 January 2018

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Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: reactivation involving flipping of the His447 ring to form a reactive Glu334-His447-oxime triad

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7 January 2021

Specific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase Inhibitors

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Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-beta-peptides

21 January 2018

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7 January 2021

New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation

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7 January 2021

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

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7 January 2021

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

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7 January 2021

New Huprine Derivatives Functionalized at Position 9 as Highly Potent Acetylcholinesterase Inhibitors

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7 January 2021

Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors

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7 January 2021