(Q27676133)

1

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Allan D'Arcy

2

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Frederic Villard

3

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Oliver Simic

4

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Marion Kamke

5

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Gaby Monnet

6

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Ulrich Hassiepen

7

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Ruth Pulfer

9

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Jörg Eder

10

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Prakash Raman

11

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Ursula Bodendorf

Proceedings of the National Academy of Sciences of the United States of America

12

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language of work or name

English

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publication date

27 December 2011

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published in

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volume

108

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issue

52

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page(s)

21052-6

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cites work

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Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

20 March 2017

1 reference

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Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications

20 March 2017

1 reference

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Induced-fit binding of the macrocyclic noncovalent inhibitor TMC435 to its HCV NS3/NS4A protease target

20 March 2017

1 reference

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Structure and functionality in flavivirus NS-proteins: perspectives for drug design

20 March 2017

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Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

20 March 2017

1 reference

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Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase

20 March 2017

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Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

20 March 2017

1 reference

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Construction, expression, and characterization of a novel fully activated recombinant single-chain hepatitis C virus protease

20 March 2017

1 reference

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

The interpretation of protein structures: Estimation of static accessibility

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

Evasion of intracellular host defence by hepatitis C virus

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

A new standard of care for the treatment of chronic HCV infection

7 April 2017

1 reference

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APRV - a program for automated data processing, refinement and visualization.

29 September 2017

1 reference

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Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3248494

The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate

2 June 2018

1 reference

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Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1110534108

Hepatitis C--pipeline update

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22160684

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An automated microseed matrix-screening method for protein crystallization

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22160684