(Q27678064)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22422993%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS (English)

1 reference

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26 January 2020

14

1 reference

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26 January 2020

Craig J Thomas

13

1 reference

ORCID Public Data File 2021

author name string

Jieqing Zhu

1

1 reference

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26 January 2020

Won-Seok Choi

2

1 reference

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26 January 2020

Joshua G McCoy

3

1 reference

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26 January 2020

Ana Negri

4

1 reference

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26 January 2020

Jianghai Zhu

5

1 reference

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26 January 2020

Sarasija Naini

6

1 reference

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26 January 2020

Jihong Li

7

1 reference

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26 January 2020

Min Shen

8

1 reference

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26 January 2020

Wenwei Huang

9

1 reference

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26 January 2020

Daniel Bougie

10

1 reference

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26 January 2020

Mark Rasmussen

11

1 reference

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26 January 2020

Richard Aster

12

1 reference

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26 January 2020

Timothy A Springer

15

1 reference

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26 January 2020

Barry S Coller

16

1 reference

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26 January 2020

language of work or name

English

0 references

publication date

1 March 2012

1 reference

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Science Translational Medicine

26 January 2020

published in

1 reference

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26 January 2020

volume

4

1 reference

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26 January 2020

issue

125

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26 January 2020

page(s)

125ra32

1 reference

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Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes

26 January 2020

cites work

1 reference

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Closed headpiece of integrin IIb 3 and its complex with an IIb 3-specific antagonist that does not induce opening

20 March 2017

1 reference

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Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

20 March 2017

1 reference

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Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

Crystal structure of the extracellular segment of integrin alpha Vbeta3

20 March 2017

1 reference

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Integrins: bidirectional, allosteric signaling machines

20 March 2017

2 references

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20 March 2017

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Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial

22 April 2017

1 reference

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Oral glycoprotein IIb/IIIa inhibitors: why don't they work?

20 March 2017

2 references

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20 March 2017

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Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials

21 January 2018

1 reference

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Heart disease and stroke statistics--2011 update: a report from the American Heart Association

20 March 2017

1 reference

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Getting to the site of inflammation: the leukocyte adhesion cascade updated

7 April 2017

1 reference

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Structural basis of integrin regulation and signaling

7 April 2017

1 reference

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Humanized mouse model of thrombosis is predictive of the clinical efficacy of antiplatelet agents

7 April 2017

1 reference

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Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding

29 September 2017

1 reference

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Early abciximab use in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention improves long-term outcome. Data from EUROTRANSFER Registry

29 September 2017

1 reference

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Integrins, growth factors, and the osteoclast cytoskeleton

29 September 2017

1 reference

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Recreation of the terminal events in physiological integrin activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

Integrins: masters and slaves of endocytic transport.

29 September 2017

1 reference

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Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

29 September 2017

1 reference

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Membrane protein assembly into Nanodiscs

29 September 2017

1 reference

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The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.

29 September 2017

1 reference

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Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.

29 September 2017

1 reference

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Eptifibatide-induced thrombocytopenia and thrombosis in humans require FcgammaRIIa and the integrin beta3 cytoplasmic domain

29 September 2017

1 reference

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The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend

29 September 2017

1 reference

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Early glycoprotein IIb-IIIa inhibitors in primary angioplasty (EGYPT) cooperation: an individual patient data meta-analysis

29 September 2017

1 reference

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Application of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.

29 September 2017

1 reference

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Eptifibatide-induced thrombocytopenia and thrombosis

29 September 2017

1 reference

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Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

29 September 2017

1 reference

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Oral GPIIb/IIIa antagonists: what went wrong?

29 September 2017

1 reference

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Structure of integrin alpha5beta1 in complex with fibronectin

29 September 2017

1 reference

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Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia

29 September 2017

1 reference

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Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.

29 September 2017

1 reference

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Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors

29 September 2017

1 reference

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A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

29 September 2017

1 reference

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Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb.

29 September 2017

1 reference

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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

29 September 2017

1 reference

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Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins.

2 June 2018

1 reference

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Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

2 June 2018

1 reference

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Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor

2 June 2018

1 reference

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Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition.

2 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003576

AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003576

Dissociation of glycoprotein IIb/IIIa antagonists from platelets does not result in fibrinogen binding or platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003576

Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3003576

In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment o

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

Incidence, patient characteristics and predictors of aborted myocardial infarction in patients undergoing primary PCI: prospective study comparing pre- and in-hospital abciximab pretreatment.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3390238

The specificity and function of the metal-binding sites in the integrin beta3 A-domain

27 November 2018

1 reference

12 December 2020

Differential expression of a ligand induced binding site (LIBS) by GPIIb-IIIa ligand recognition peptides and parenteral antagonists

1 reference

12 December 2020

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

1 reference

12 December 2020

Association between ligand-induced conformational changes of integrin IIbbeta3 and IIbbeta3-mediated intracellular Ca2+ signaling

1 reference

12 December 2020

Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction

1 reference

12 December 2020

Restoration of coronary flow in myocardial infarction by intravenous chimeric 7E3 antibody without exogenous plasminogen activators. Observations in animals and humans

1 reference

12 December 2020

10.1126/SCITRANSLMED.3003576

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22422993%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22422993%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

22422993

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22422993%20AND%20SRC:MED&resulttype=core&format=json