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NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
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title
NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
(English)
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author
Angela Gronenborn
object named as
Angela M Gronenborn
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9
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author name string
In-Ja L Byeon
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1
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Jinwoo Ahn
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2
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Mithun Mitra
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3
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Chang-Hyeock Byeon
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4
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Kamil Hercík
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5
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Jozef Hritz
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6
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Lisa M Charlton
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7
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Judith G Levin
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8
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language of work or name
English
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publication date
2013
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published in
Nature Communications
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volume
4
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page(s)
1890
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ImageQuant
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Europe PubMed Central
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3674325/fullTextXML
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cites work
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APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1
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Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities
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20 March 2017
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces
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APOBEC3 proteins mediate the clearance of foreign DNA from human cells
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Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase
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An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model
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Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G
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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications
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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G
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All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition
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APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons
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NMR View: A computer program for the visualization and analysis of NMR data
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Protein backbone angle restraints from searching a database for chemical shift and sequence homology
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APOBEC3B is an enzymatic source of mutation in breast cancer.
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29 September 2017
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.
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A simultaneous (15)N, (1)H- and (13)C, (1)H-HSQC with sensitivity enhancement and a heteronuclear gradient echo
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29 September 2017
Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A
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29 September 2017
Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.
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29 September 2017
Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G.
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29 September 2017
Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.
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29 September 2017
Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.
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29 September 2017
APOBEC2 is a monomer in solution: implications for APOBEC3G models
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29 September 2017
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
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PubMed Central
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29 September 2017
Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.
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29 September 2017
Fast flexible modeling of RNA structure using internal coordinates.
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29 September 2017
APOBEC3A can activate the DNA damage response and cause cell-cycle arrest
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
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PubMed Central
reference URL
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29 September 2017
Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
The current structural and functional understanding of APOBEC deaminases
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PubMed Central
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29 September 2017
APOBEC proteins and intrinsic resistance to HIV-1 infection
1 reference
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PubMed Central
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29 September 2017
Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Vpr.A3A chimera inhibits HIV replication
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29 September 2017
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G.
1 reference
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PubMed Central
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29 September 2017
Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Myeloid differentiation and susceptibility to HIV-1 are linked to APOBEC3 expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
APOBEC3 proteins inhibit human LINE-1 retrotransposition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Biochemical activities of highly purified, catalytically active human APOBEC3G: correlation with antiviral effect.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Cellular inhibitors of long interspersed element 1 and Alu retrotransposition.
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29 September 2017
APOBEC3G DNA deaminase acts processively 3' --> 5' on single-stranded DNA.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3674325
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29 September 2017
Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex
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29 September 2017
Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.
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2 June 2018
Determining the structures of large proteins and protein complexes by NMR.
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2 June 2018
Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.
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2 June 2018
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.
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27 November 2018
Complementary function of the two catalytic domains of APOBEC3G.
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27 November 2018
Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity
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27 November 2018
Identifiers
DOI
10.1038/NCOMMS2883
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2005374
ADS bibcode
2013NatCo...4.1890B
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Dimensions Publication ID
1007409494
0 references
OpenCitations bibliographic resource ID
2005374
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2005374
PMCID
3674325
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2005374
PubMed ID
23695684
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2005374
ResearchGate publication ID
236929698
0 references
Springer Nature article ID
10.1038/ncomms2883
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