(Q27678595)

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Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV ( -TRTX-Hh2a)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23760503%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a) (English)

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3 March 2020

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3 March 2020

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Natali A Minassian

1

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3 March 2020

Amy Y Shih

3

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3 March 2020

Yi Liu

4

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3 March 2020

Robert A Neff

5

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3 March 2020

Steven W Sutton

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3 March 2020

Tara Mirzadegan

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3 March 2020

Judith Connor

8

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3 March 2020

Ross Fellows

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3 March 2020

Matthew Husovsky

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3 March 2020

Serena Nelson

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3 March 2020

Michael J Hunter

12

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3 March 2020

Mack Flinspach

13

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3 March 2020

Alan D Wickenden

14

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3 March 2020

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12 June 2013

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3 March 2020

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14

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Journal of Biological Chemistry

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3 March 2020

288

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3 March 2020

31

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3 March 2020

22707-22720

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3 March 2020

The crystal structure of a voltage-gated sodium channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

20 March 2017

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

20 March 2017

Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

20 March 2017

PREDITOR: a web server for predicting protein torsion angle restraints

1 reference

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20 March 2017

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus

1 reference

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20 March 2017

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

1 reference

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20 March 2017

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

20 March 2017

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins

1 reference

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20 March 2017

Scalable molecular dynamics with NAMD

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20 March 2017

Automated NMR structure calculation with CYANA

1 reference

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20 March 2017

VMD: visual molecular dynamics

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20 March 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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20 March 2017

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

1 reference

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20 March 2017

Unraveling the genetics and mechanisms of cardiac arrhythmia

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20 March 2017

An SCN9A channelopathy causes congenital inability to experience pain

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20 March 2017

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

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7 April 2017

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

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7 April 2017

Mapping the interaction site for a β-scorpion toxin in the pore module of domain III of voltage-gated Na(+) channels

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29 September 2017

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

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29 September 2017

Spider-venom peptides as therapeutics.

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29 September 2017

Structure-function map of the receptor site for β-scorpion toxins in domain II of voltage-gated sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation

1 reference

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29 September 2017

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel

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29 September 2017

Prediction of protein-protein interaction sites using electrostatic desolvation profiles

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

1 reference

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29 September 2017

DANGLE: A Bayesian inferential method for predicting protein backbone dihedral angles and secondary structure.

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29 September 2017

ArachnoServer: a database of protein toxins from spiders

1 reference

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29 September 2017

Peptide toxins that selectively target insect Na(V) and Ca(V) channels

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29 September 2017

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

A stop codon mutation in SCN9A causes lack of pain sensation

1 reference

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29 September 2017

Molecular diversification in spider venoms: a web of combinatorial peptide libraries

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29 September 2017

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

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29 September 2017

Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels.

1 reference

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29 September 2017

Ion channels as important targets for antiepileptic drug design

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29 September 2017

Voltage-gated sodium channels and pain pathways

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29 September 2017

Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels

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29 September 2017

Two tarantula peptides inhibit activation of multiple sodium channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3829356

29 September 2017

Spectrum of sodium channel disturbances in the nondystrophic myotonias and periodic paralyses

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29 September 2017

Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena

1 reference

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29 September 2017

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

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2 June 2018

The wonderful world of spiders: preface to the special Toxicon issue on spider venoms.

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21 January 2018

Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV

1 reference

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21 January 2018

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

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21 January 2018

Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers

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21 January 2018

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels

1 reference

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12 December 2020

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10.1074/JBC.M113.461392

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3 March 2020

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2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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3 March 2020

PubMed publication ID

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Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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3 March 2020

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