(Q27678891)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558288%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

Assessment of Pseudomonas aeruginosa N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase as a potential antibacterial drug target (English)

1 reference

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31 January 2020

main subject

Pseudomonas aeruginosa

0 references

author

David W. Gray

7

1 reference

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31 January 2020

William Nigel Hunter

8

1 reference

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31 January 2020

author name string

Thomas C Eadsforth

1

1 reference

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31 January 2020

Mary Gardiner

2

1 reference

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31 January 2020

Fernando V Maluf

3

1 reference

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31 January 2020

Stuart McElroy

4

1 reference

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31 January 2020

Daniel James

5

1 reference

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31 January 2020

Julie Frearson

6

1 reference

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31 January 2020

language of work or name

English

0 references

publication date

25 April 2012

1 reference

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31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558288%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

volume

7

1 reference

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31 January 2020

issue

4

1 reference

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31 January 2020

page(s)

e35973

1 reference

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Creative Commons Attribution 4.0 International

31 January 2020

copyright license

start time

25 April 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target

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Crystal Structures of Penicillin-Binding Protein 3 from Pseudomonas aeruginosa: Comparison of Native and Antibiotic-Bound Forms

20 March 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

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Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

20 March 2017

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20 March 2017

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Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase

20 March 2017

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The crystal structure of a bacterial, bifunctional 5, 10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase

20 March 2017

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The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution

20 March 2017

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Features and development of Coot

20 March 2017

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20 March 2017

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

20 March 2017

1 reference

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Scaling and assessment of data quality

20 March 2017

1 reference

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The integration of macromolecular diffraction data

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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20 March 2017

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

20 March 2017

1 reference

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338484

Drugs for bad bugs: confronting the challenges of antibacterial discovery

7 April 2017

1 reference

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Comprehensive transposon mutant library of Pseudomonas aeruginosa

7 April 2017

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High-density miniaturized thermal shift assays as a general strategy for drug discovery

7 April 2017

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Structure-based druggability assessment--identifying suitable targets for small molecule therapeutics

7 April 2017

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Pseudomonas aeruginosa: a formidable and ever-present adversary

29 September 2017

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Staphylococcus aureus bloodstream infections: definitions and treatment

29 September 2017

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Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major

29 September 2017

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Structure-based ligand design and the promise held for antiprotozoan drug discovery.

29 September 2017

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A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1.

29 September 2017

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Target assessment for antiparasitic drug discovery

29 September 2017

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A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate

29 September 2017

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Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate

29 September 2017

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Dihydrofolate reductase inhibitors as antibacterial agents

29 September 2017

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Pocketome via comprehensive identification and classification of ligand binding envelopes.

29 September 2017

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National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002.

29 September 2017

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Antimicrobial dihydrofolate reductase inhibitors--achievements and future options: review

29 September 2017

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The abandonment of antibacterials: why and wherefore?

29 September 2017

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Folic acid: nutritional biochemistry, molecular biology, and role in disease processes

29 September 2017

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Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338484

Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999.

29 September 2017

1 reference

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Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035973

A solution for the best rotation to relate two sets of vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035973

Residues involved in the mechanism of the bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase: the roles of glutamine 100 and aspartate 125.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0035973

The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine

21 January 2018

1 reference

12 December 2020

Methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase. A multifunctional protein from porcine liver

1 reference

12 December 2020

Physicochemical properties of antibacterial compounds: implications for drug discovery

1 reference

12 December 2020

LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0035973

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558288%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558288%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

22558288

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558288%20AND%20SRC:MED&resulttype=core&format=json