(Q27679017)

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Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

scientific article

Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)

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scholarly article

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Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1) (English)

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6

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Titus J Boggon

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author name string

Xiaofeng Li

1

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Rong Zhang

2

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Kyle M Draheim

3

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Weizhi Liu

4

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David A Calderwood

5

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language of work or name

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publication date

22 June 2012

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Journal of Biological Chemistry

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287

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26

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22317-27

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Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

1 reference

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20 March 2017

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

1 reference

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20 March 2017

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

1 reference

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20 March 2017

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

1 reference

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20 March 2017

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Specificity in Ras and Rap signaling

1 reference

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20 March 2017

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II

1 reference

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20 March 2017

The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

1 reference

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20 March 2017

Structural basis for the autoinhibition of focal adhesion kinase

1 reference

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20 March 2017

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

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ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

1 reference

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20 March 2017

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

1 reference

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20 March 2017

Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Structural determinants of integrin recognition by talin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

PDBsum: summaries and analyses of PDB structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Structural basis for the interaction of Ras with RalGDS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Ras/Rap effector specificity determined by charge reversal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Clustal W and Clustal X version 2.0

1 reference

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20 March 2017

Inference of macromolecular assemblies from crystalline state

1 reference

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20 March 2017

Likelihood-enhanced fast translation functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Coot: model-building tools for molecular graphics

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

The CCP4 suite: programs for protein crystallography

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

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20 March 2017

PHENIX: building new software for automated crystallographic structure determination

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

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21 January 2018

ARP/wARP and molecular replacement

1 reference

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20 March 2017

Dali: a network tool for protein structure comparison

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Shape complementarity at protein/protein interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

GEFs and GAPs: critical elements in the control of small G proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

20 March 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

7 April 2017

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

7 April 2017

Cerebral cavernous malformations: from genes to proteins to disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

The FERM domain: organizing the structure and function of FAK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Integrin cytoskeletal interactions.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Cerebral cavernous malformation: new molecular and clinical insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Phylogenetic analysis using PHYLIP.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

The N-termini of FAK and JAKs contain divergent band 4.1 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

29 September 2017

Talin and signaling through integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

2 June 2018

Structural basis for NHERF recognition by ERM proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381192

2 June 2018

Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.361295

21 January 2018

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.361295

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.361295

21 January 2018

Identifiers

10.1074/JBC.M112.361295

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