(Q34924413)

5 August 2017

title

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases (English)

1 reference

5 August 2017

Douglas A Marchuk

11

1 reference

ORCID Public Data File 2021

author name string

Kevin J Whitehead

1

1 reference

5 August 2017

Aubrey C Chan

2

1 reference

5 August 2017

Sutip Navankasattusas

3

1 reference

5 August 2017

Wonshill Koh

4

1 reference

5 August 2017

Nyall R London

5

1 reference

5 August 2017

Jing Ling

6

1 reference

5 August 2017

Anne H Mayo

7

1 reference

5 August 2017

Stavros G Drakos

8

1 reference

5 August 2017

Christopher A Jones

9

1 reference

5 August 2017

Weiquan Zhu

10

1 reference

5 August 2017

George E Davis

12

1 reference

5 August 2017

Dean Y Li

13

1 reference

5 August 2017

language of work or name

English

0 references

publication date

18 January 2009

1 reference

5 August 2017

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5 August 2017

volume

15

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5 August 2017

issue

2

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5 August 2017

page(s)

177-184

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.1911

5 August 2017

exact match

0 references

cites work

The netrin receptor UNC5B promotes angiogenesis in specific vascular beds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

CCM2 expression parallels that of CCM1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Mutations within the MGC4607 gene cause cerebral cavernous malformations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Rho GTPases control polarity, protrusion, and adhesion during cell movement

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Formation of intracerebral cavernous malformations after radiation treatment for central nervous system neoplasia in children

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Mechanisms of angiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Sounding the alarm: protein kinase cascades activated by stress and inflammation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Natural history of the cavernous angioma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Clinically documented hemorrhage in cerebral arteriovenous malformations: MR characteristics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Long-term results after stereotactic radiosurgery for patients with cavernous malformations.

8 July 2018

1 reference

Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development.

21 January 2018

1 reference

Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.

21 January 2018

1 reference

Nestin-Cre mediated deletion of Pitx2 in the mouse.

21 January 2018

1 reference

Endothelial tubes assemble from intracellular vacuoles in vivo

21 January 2018

1 reference

Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho.

21 January 2018

1 reference

Cerebral cavernous malformations with dynamic and progressive course: correlation study with vascular endothelial growth factor

21 January 2018

1 reference

Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.

21 January 2018

1 reference

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

21 January 2018

1 reference

Isoprenylation is necessary for the full invasive potential of RhoA overexpression in human melanoma cells

21 January 2018

1 reference

Src Family Kinases Promote Vessel Stability by Antagonizing the Rho/ROCK Pathway

21 January 2018

1 reference

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

21 January 2018

1 reference

Vertebral and spinal cavernous angiomas associated with familial cerebral cavernous malformation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

Rho and Rac but not Cdc42 regulate endothelial cell permeability.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767168

ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis

26 October 2018

1 reference

Selective ablation of v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death

21 January 2018

1 reference

12 December 2020

High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice

1 reference

12 December 2020

Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation

1 reference

12 December 2020

A targeted X-linked CMV-Cre line

1 reference

12 December 2020

[131 cases of cavernous angioma (cavernomas) of the CNS, discovered by retrospective analysis of 24,535 autopsies]

1 reference

12 December 2020

ADP-ribosylation by Clostridium botulinum C3 exoenzyme increases steady-state GTPase activities of recombinant rhoA and rhoB proteins

1 reference

12 December 2020

An alpha 2 beta 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix

1 reference

12 December 2020

Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.1911

1 reference

Dimensions Publication ID

5 August 2017

0 references

1 reference

5 August 2017

1 reference