(Q27680405)

2

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Elena Rusinova

3

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Tong Shen

4

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Keita Morohashi

5

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Jennifer Joshua

6

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Lei Zeng

7

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Shiraz Mujtaba

8

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Michael Ohlmeyer

9

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Ming-Ming Zhou

Journal of Medicinal Chemistry

10

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language of work or name

English

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publication date

27 November 2013

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published in

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volume

56

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issue

22

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page(s)

9251-64

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cites work

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Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

20 March 2017

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Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition

20 March 2017

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Histone recognition and large-scale structural analysis of the human bromodomain family

20 March 2017

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Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

20 March 2017

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Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

20 March 2017

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

20 March 2017

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A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

20 March 2017

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Suppression of inflammation by a synthetic histone mimic

20 March 2017

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Selective inhibition of BET bromodomains

20 March 2017

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The role of human bromodomains in chromatin biology and gene transcription

20 March 2017

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Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

20 March 2017

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Structure and ligand of a histone acetyltransferase bromodomain

20 March 2017

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Chromatin modifications and their function

20 March 2017

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20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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BET domain co-regulators in obesity, inflammation and cancer

20 March 2017

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

20 March 2017

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BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

7 April 2017

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Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

29 September 2017

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Physiochemical drug properties associated with in vivo toxicological outcomes

29 September 2017

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NF-kappaB-dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts

29 September 2017

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Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis

29 September 2017

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Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

2 June 2018

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An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs

2 June 2018

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Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

27 November 2018

1 reference

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Contributions of molecular properties to drug promiscuity

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24144283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24144283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM401334S

1 reference

1 reference

1 reference

PubMed publication ID

24144283

1 reference