(Q27681061)

6

0 references

Thibaut Crépin

object named as

Thibaut Crépin

2

0 references

Andrés Palencia

object named as

Andrés Palencia

1

0 references

author name string

Michael T Vu

3

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Tommie L Lincecum

4

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Susan A Martinis

Nature Structural & Molecular Biology

5

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publication date

10 June 2012

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published in

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volume

19

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issue

7

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page(s)

677-84

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cites work

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural bases of transfer RNA-dependent amino acid recognition and activation by glutamyl-tRNA synthetase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Amino acid discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

The 2 Å crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

How glutaminyl-tRNA synthetase selects glutamine

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

Likelihood-enhanced fast translation functions

22 April 2017

1 reference

Automated protein model building combined with iterative structure refinement

22 April 2017

1 reference

Coot: model-building tools for molecular graphics

22 April 2017

1 reference

MolProbity: all-atom structure validation for macromolecular crystallography

22 April 2017

1 reference

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

22 April 2017

1 reference

Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Amino acid toxicities of Escherichia coli that are prevented by leucyl-tRNA synthetase amino acid editing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

A unique insert of leucyl-tRNA synthetase is required for aminoacylation and not amino acid editing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Major biocontrol of plant tumors targets tRNA synthetase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Structural snapshots of the KMSKS loop rearrangement for amino acid activation by bacterial tyrosyl-tRNA synthetase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Identification of essential domains for Escherichia coli tRNA(leu) aminoacylation and amino acid editing using minimalist RNA molecules

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

Evolutionary basis for the coupled-domain motions in Thermus thermophilus leucyl-tRNA synthetase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

tRNA leucine identity and recognition sets

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392462

The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation

2 June 2018

1 reference

Editing mechanism of aminoacyl-tRNA synthetases operates by a hybrid ribozyme/protein catalyst

21 January 2018

1 reference

Crystal structure of leucyl-tRNA synthetase from the archaeon Pyrococcus horikoshii reveals a novel editing domain orientation

21 January 2018

1 reference

Shape-selective RNA recognition by cysteinyl-tRNA synthetase

21 January 2018

1 reference

E292 Is Important for the Aminoacylation Activity of Escherichia coli Leucyl-tRNA Synthetase

21 January 2018

1 reference

An aminoacyl-tRNA synthetase with a defunct editing site.

21 January 2018

1 reference

Active-site assembly in glutaminyl-tRNA synthetase by tRNA-mediated induced fit.

21 January 2018

1 reference

Crystal structures of the editing domain of Escherichia coli leucyl-tRNA synthetase and its complexes with Met and Ile reveal a lock-and-key mechanism for amino acid discrimination

21 January 2018

1 reference

Aminoacylation complex structures of leucyl-tRNA synthetase and tRNALeu reveal two modes of discriminator-base recognition

21 January 2018

1 reference

The peptide bond between E292-A293 of Escherichia coli leucyl-tRNA synthetase is essential for its activity

21 January 2018

1 reference

Improvements in the analysis of domain motions in proteins from conformational change: DynDom version 1.50

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2317

1 reference

Dimensions Publication ID

1375631

1019408896

0 references

1375631

1 reference

1 reference

1 reference