(Q27684091)

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16 June 2025

author name string

Eric Garver

18

1 reference

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16 June 2025

Lusong Luo

23

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16 June 2025

Kaushik Raha

24

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16 June 2025

Chiu-Mei Sung

26

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16 June 2025

David Sutton

27

1 reference

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16 June 2025

Dashyant Dhanak

31

1 reference

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16 June 2025

Steven D. Knight

1

1 reference

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16 June 2025

Nicholas D. Adams

2

1 reference

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16 June 2025

Joelle L. Burgess

3

1 reference

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16 June 2025

Amita M. Chaudhari

4

1 reference

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16 June 2025

Michael G. Darcy

5

1 reference

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16 June 2025

Carla A. Donatelli

6

1 reference

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16 June 2025

Juan I. Luengo

7

1 reference

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16 June 2025

Ken A. Newlander

8

1 reference

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16 June 2025

Cynthia A. Parrish

9

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16 June 2025

Lance H. Ridgers

10

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16 June 2025

Martha A. Sarpong

11

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16 June 2025

Stanley J. Schmidt

12

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16 June 2025

Glenn S. Van Aller

13

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16 June 2025

Jeffrey D. Carson

14

1 reference

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16 June 2025

Melody A. Diamond

15

1 reference

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16 June 2025

Patricia A. Elkins

16

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16 June 2025

Christine M. Gardiner

17

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Seth A. Gilbert

19

1 reference

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16 June 2025

Richard R. Gontarek

20

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Jeffrey R. Jackson

21

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16 June 2025

Kevin L. Kershner

22

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16 June 2025

Christian S. Sherk

25

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16 June 2025

Peter J. Tummino

28

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16 June 2025

Ronald J. Wegrzyn

29

1 reference

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Kurt R. Auger

30

1 reference

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16 June 2025

publication date

8 April 2010

0 references

19 January 2010

1 reference

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16 June 2025

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=24900173

https://europepmc.org/articles/pmc4007793?pdf=render

16 June 2025

work available at URL

1 reference

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https://europepmc.org/articles/PMC4007793

16 June 2025

file format

HyperText Markup Language

online access status

open access

content deliverer

1 reference

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16 June 2025

1 reference

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https://doi.org/10.1021/ml900028r

16 June 2025

online access status

open access

1 reference

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https://pubs.acs.org/doi/pdf/10.1021/ml900028r

16 June 2025

1 reference

https://api.crossref.org/works/10.1021/ML900028R

ACS Medicinal Chemistry Letters

16 June 2025

published in

1 reference

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Crossref

volume

1

0 references

issue

1

0 references

page(s)

39-43

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

20 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

High frequency of mutations of the PIK3CA gene in human cancers

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Signaling by distinct classes of phosphoinositide 3-kinases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Ras, PI(3)K and mTOR signalling controls tumour cell growth

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Advances in development of phosphatidylinositol 3-kinase inhibitors

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Cancer-specific mutations in phosphatidylinositol 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Mutation of the PIK3CA oncogene in human cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Cancer-specific mutations in PIK3CA are oncogenic in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

Structural insights into phosphoinositide 3-kinase catalysis and signalling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4007793

27 November 2018

Identifiers

DOI

10.1021/ML900028R

1 reference

1 reference

1 reference

1 reference