(Q27649316)

7

0 references

Kenneth W. Kinzler

6

0 references

L. Mario Amzel

9

0 references

Victor Velculescu

5

0 references

Chuan-Hsiang Huang

Chuan-Hsiang Huang

1

0 references

Sandra B. Gabelli

Sandra B Gabelli

8

0 references

Yardena Samuels

Yardena Samuels

4

0 references

Diana Mandelker

2

Diana Mandelker

0 references

Oleg Schmidt-Kittler

3

Signaling by distinct classes of phosphoinositide 3-kinases

Oleg Schmidt-Kittler

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language of work or name

English

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publication date

14 December 2007

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published in

Science

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volume

318

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page(s)

1744-8

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issue

5857

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cites work

1 reference

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The phosphoinositide 3-kinase pathway

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Regulation of cell death protease caspase-9 by phosphorylation

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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The biology and clinical relevance of the PTEN tumor suppressor pathway

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Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

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AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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High frequency of mutations of the PIK3CA gene in human cancers

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

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Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

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Oncogenic PI3K deregulates transcription and translation

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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PIK3CA is implicated as an oncogene in ovarian cancer.

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Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components

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Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

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Frequent mutation of the PIK3CA gene in ovarian and breast cancers.

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Cancer-specific mutations in phosphatidylinositol 3-kinase

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

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Cancer-specific mutations in PIK3CA are oncogenic in vivo

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

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The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

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Rare cancer-specific mutations in PIK3CA show gain of function

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

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Chemically targeting the PI3K family

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

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