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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
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scholarly article
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title
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
(English)
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main subject
organic chemistry
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drug discovery
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author name string
Binh Vu
series ordinal
1
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Peter Wovkulich
series ordinal
2
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Giacomo Pizzolato
series ordinal
3
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Allen Lovey
series ordinal
4
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Qingjie Ding
series ordinal
5
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Nan Jiang
series ordinal
6
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Jin-Jun Liu
series ordinal
7
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Chunlin Zhao
series ordinal
8
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Kelli Glenn
series ordinal
9
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Yang Wen
series ordinal
10
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Christian Tovar
series ordinal
11
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Kathryn Packman
series ordinal
12
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Lyubomir Vassilev
series ordinal
13
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Bradford Graves
series ordinal
14
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language of work or name
English
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publication date
9 May 2013
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published in
ACS Medicinal Chemistry Letters
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stated in
Crossref
volume
4
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issue
5
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page(s)
466-9
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cites work
MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
Structure-based design of novel inhibitors of the MDM2-p53 interaction
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PubMed Central
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20 March 2017
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
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PubMed Central
reference URL
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retrieved
20 March 2017
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
1 reference
stated in
PubMed Central
reference URL
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retrieved
20 March 2017
Surfing the p53 network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145
retrieved
7 April 2017
Regulation of p53 stability by Mdm2
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
p53, the cellular gatekeeper for growth and division
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PubMed Central
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20 March 2017
Functions of the MDM2 oncoprotein
1 reference
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PubMed Central
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20 March 2017
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
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PubMed Central
reference URL
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20 March 2017
The p53 pathway: positive and negative feedback loops
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PubMed Central
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7 April 2017
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
1 reference
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PubMed Central
reference URL
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29 September 2017
Recent advances in the therapeutic perspectives of Nutlin-3.
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29 September 2017
Small-molecule inhibitors of the p53-MDM2 interaction
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PubMed Central
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29 September 2017
Awakening guardian angels: drugging the p53 pathway
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29 September 2017
MDM2 inhibitors for cancer therapy
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PubMed Central
reference URL
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29 September 2017
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145
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29 September 2017
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
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PubMed Central
reference URL
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29 September 2017
MDM2 is a central node in the p53 pathway: 12 years and counting
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PubMed Central
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29 September 2017
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.
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29 September 2017
MDM2, an introduction.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145
retrieved
29 September 2017
Regulation of p53 stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145
retrieved
29 September 2017
p53 and human cancer: the first ten thousand mutations.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027145
retrieved
29 September 2017
Identifiers
DOI
10.1021/ML4000657
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1648199
Fatcat ID
release_fnzukap4lzegzojx2aldkwy3pu
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/fnzukap4lzegzojx2aldkwy3pu
retrieved
24 November 2022
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mapped directly with Wikidata item
OpenCitations bibliographic resource ID
1648199
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1648199
PMC publication ID
4027145
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1648199
PubMed publication ID
24900694
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1648199
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