(Q27684924)

2

0 references

Lise-Lotte Olsson

3

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Susan B Fowler

4

0 references

Sarah Digby

5

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Alan Sandercock

6

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Arjan Snijder

7

0 references

Jan Tebbe

8

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Ulrich Haupts

9

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Joanna Grudzinska

10

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Lutz Jermutus

11

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Christin Andersson

Creative Commons Attribution 4.0 International

12

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language of work or name

English

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publication date

2014

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published in

PLOS One

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volume

9

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issue

8

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page(s)

e104001

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copyright license

start time

4 August 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

20 March 2017

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

20 March 2017

1 reference

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Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease

20 March 2017

1 reference

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Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV

20 March 2017

1 reference

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Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

20 March 2017

1 reference

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Structural analysis of neprilysin with various specific and potent inhibitors

20 March 2017

1 reference

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Thermolysin in the absence of substrate has an open conformation

20 March 2017

1 reference

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Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

20 March 2017

1 reference

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Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11

20 March 2017

1 reference

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Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

20 March 2017

1 reference

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Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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The conformation of thermolysin

20 March 2017

1 reference

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

20 March 2017

1 reference

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New function for an old enzyme: NEP deficient mice develop late-onset obesity

20 March 2017

1 reference

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Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β.

20 March 2017

1 reference

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Active site mutations change the cleavage specificity of neprilysin

29 September 2017

1 reference

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Alteration of substrate specificity of rat neurolysin from matrix metalloproteinase-2/9-type to -3-type specificity by comprehensive mutation

29 September 2017

1 reference

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Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

29 September 2017

1 reference

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Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease

29 September 2017

1 reference

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Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

29 September 2017

1 reference

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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice.

29 September 2017

1 reference

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Regulatory peptide metabolism at cell surfaces: the key role of endopeptidase-24.11.

29 September 2017

1 reference

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Degradation of atrial natriuretic peptide: pharmacologic effects of protease EC 24.11 inhibition.

29 September 2017

1 reference

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Metabolism and functions of neuropeptide Y.

29 September 2017

1 reference

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The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.

2 June 2018

1 reference

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The molecular weight and properties of a neutral metallo-endopeptidase from rabbit kidney brush border

2 June 2018

1 reference

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Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4121237

Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-β42 and thiorphan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

MOLREP: an Automated Program for Molecular Replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Enhanced proteolytic clearance of plasma Aβ by peripherally administered neprilysin does not result in reduced levels of brain Aβ in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104001

Substrate and inhibitor studies of thermolysin-like neutral metalloendopeptidase from kidney membrane fractions. Comparison with bacterial thermolysin

21 January 2018

1 reference

12 December 2020

Proadrenomedullin N-terminal 20 peptide is rapidly cleaved by neutral endopeptidase

1 reference

12 December 2020

A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11)

1 reference

12 December 2020

Renal and Depressor Effects of SQ 29,072, a Neutral Endopeptidase Inhibitor, in Conscious Hypertensive Rats

1 reference

12 December 2020

β-Amyloid and Neprilysin Computational Studies Identify Critical Residues Implicated in Binding Specificity

1 reference

12 December 2020

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0104001

Identifiers

DOI

1 reference

ADS bibcode

2014PLoSO...9j4001W

0 references

1 reference

1 reference

PubMed publication ID

25089527

1 reference