(Q27695715)

4

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author name string

Susanne Terheyden

1

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Franz Y Ho

2

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Bernd K Gilsbach

3

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Arjan Kortholt

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

5

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language of work or name

English

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publication date

1 January 2015

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published in

Biochemical Journal

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volume

465

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issue

1

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page(s)

139-47

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cites work

1 reference

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

20 April 2017

1 reference

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

20 April 2017

1 reference

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

20 April 2017

1 reference

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

20 April 2017

1 reference

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

20 April 2017

1 reference

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

20 April 2017

1 reference

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

20 April 2017

1 reference

Direct binding of alpha-actinin enhances TRPP3 channel activity

20 April 2017

1 reference

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

20 April 2017

1 reference

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

20 April 2017

1 reference

The guanine nucleotide-binding switch in three dimensions

20 April 2017

1 reference

The GTPase superfamily: conserved structure and molecular mechanism

20 April 2017

1 reference

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

20 April 2017

1 reference

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

20 April 2017

1 reference

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

20 April 2017

1 reference

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

20 April 2017

1 reference

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Roc, a Ras/GTPase domain in complex proteins

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Parkinson's disease: insights from pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Kinase drug discovery--what's next in the field?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Number and brightness analysis of LRRK2 oligomerization in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

It takes two to tango: regulation of G proteins by dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20141095