(Q27723745)

29

0 references

Laurent Salphati

13

Laurent Salphati

0 references

Anneleen Daemen

27

Anneleen Daemen

0 references

Hans E Purkey

2

Hans E Purkey

0 references

Shiva Malek

31

Shiva Malek

0 references

Ivana Yen

20

Ivana Yen

0 references

Steve Sideris

21

Steve Sideris

0 references

author name string

Aaron Boudreau

1

0 references

Anna Hitz

3

0 references

Kirk Robarge

4

0 references

David Peterson

5

0 references

Mandy Kwong

7

0 references

Rebecca Hong

8

0 references

Min Gao

9

0 references

Christopher Del Nagro

10

0 references

Raju Pusapati

11

0 references

Shuguang Ma

12

0 references

Jodie Pang

14

0 references

Aihe Zhou

15

0 references

Tommy Lai

16

0 references

Yingjie Li

17

0 references

Zhongguo Chen

18

0 references

Binqing Wei

19

0 references

Mark McCleland

22

0 references

Ron Firestein

23

0 references

Laura Corson

24

0 references

Alex Vanderbilt

25

0 references

Simon Williams

26

0 references

Marcia Belvin

28

0 references

Peter K Jackson

30

0 references

Georgia Hatzivassiliou

32

0 references

Deepak Sampath

33

0 references

Marie Evangelista

34

0 references

Thomas O'Brien

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

35

0 references

publication date

October 2016

0 references

published in

Nature Chemical Biology

0 references

volume

12

0 references

issue

10

0 references

page(s)

779-86

0 references

cites work

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

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Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

21 April 2017

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Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

21 April 2017

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Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

21 April 2017

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TSC2 mediates cellular energy response to control cell growth and survival

21 April 2017

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 April 2017

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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

21 April 2017

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 April 2017

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Molecular mechanisms of mTOR-mediated translational control

21 April 2017

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Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy

21 April 2017

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Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors

21 January 2018

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Tetravalent antibody-scTRAIL fusion proteins with improved properties

21 January 2018

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

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Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha

21 January 2018

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On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.

21 January 2018

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Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

21 January 2018

1 reference

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Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

21 January 2018

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N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

21 January 2018

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Label-free high-throughput assays to screen and characterize novel lactate dehydrogenase inhibitors

21 January 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 January 2018

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Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria

21 January 2018

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Systematic discovery of multicomponent therapeutics

21 January 2018

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AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

21 January 2018

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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

21 January 2018

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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

21 January 2018

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

21 January 2018

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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

21 January 2018

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Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

21 January 2018

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pHUSH: a single vector system for conditional gene expression

21 January 2018

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Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group

21 January 2018

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Lactic dehydrogenase. V. Inhibition by oxamate and by oxalate

21 January 2018

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12 December 2020

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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12 December 2020

Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species.

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12 December 2020

Inhibition of lactic acid dehydrogenase by fluoropyruvic acid

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12 December 2020

AMPK: a cellular metabolic and redox sensor. A minireview

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12 December 2020

Kinetic properties of NAD-dependent glyceraldehyde-3-phosphate dehydrogenase from the host fraction of soybean root nodules

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12 December 2020

Regulation of glyceraldehyde-3-phosphate dehydrogenase by a cytosolic protein

1 reference

12 December 2020