(Q27727694)

9

0 references

Willem Nissink

12

object named as

J Willem M Nissink

0 references

Steven J Shaw

object named as

Steven J Shaw

4

0 references

Thomas A Ward

object named as

Thomas A Ward

6

0 references

author name string

Jack C Exell

1

0 references

Mark J Thompson

2

0 references

L David Finger

3

0 references

Judit Debreczeni

5

0 references

Claire McWhirter

7

0 references

Catrine L B Siöberg

8

0 references

W Mark Abbott

10

0 references

Clifford D Jones

11

0 references

J Willem M Nissink

12

0 references

Stephen T Durant

13

0 references

Jane A Grasby

full work available at URL

14

0 references

language of work or name

1 reference

October 2016

0 references

http://eprints.whiterose.ac.uk/118189

content deliverer

White Rose Research Online

object of statement has role

postprint

1 reference

White Rose Research Online

http://eprints.whiterose.ac.uk/118189

An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development

15 December 2018

published in

Nature Chemical Biology

0 references

volume

12

0 references

issue

10

0 references

page(s)

815-21

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Features and development of Coot

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

How the fanconi anemia pathway guards the genome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

FEN1 is overexpressed in testis, lung and brain tumors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Protein production by auto-induction in high density shaking cultures

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Enzymes and reactions at the eukaryotic DNA replication fork

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Reconstitution of complete SV40 DNA replication with purified replication factors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

CtIP mediates replication fork recovery in a FANCD2-regulated manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Inhibiting the HIV integration process: past, present, and the future.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Pharmacokinetics and the drug-target residence time concept

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The wonders of flap endonucleases: structure, function, mechanism and regulation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

High-precision isothermal titration calorimetry with automated peak-shape analysis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Telomerase-independent paths to immortality in predictable cancer subtypes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Functional regulation of FEN1 nuclease and its link to cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Cleavable C-terminal His-tag vectors for structure determination.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Amino acid Asp181 of 5'-flap endonuclease 1 is a useful target for chemotherapeutic development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Structure and mechanism of DNA polymerase Beta.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Structural basis for recruitment of human flap endonuclease 1 to PCNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Envisioning the molecular choreography of DNA base excision repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5348030

Involvement of flap endonuclease 1 in base excision DNA repair.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Defective flap endonuclease 1 activity in mammalian cells is associated with impaired DNA repair and prolonged S phase delay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Gene expression analysis identifies global gene dosage sensitivity in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2148

Fluorescence resonance energy transfer analysis of the structure of the four-way DNA junction

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27526030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27526030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural changes measured by X-ray scattering from human flap endonuclease-1 complexed with Mg2+ and flap DNA substrate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27526030