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AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines
scientific article
AZD1480 Blocks Growth and Tumorigenesis of RET- Activated Thyroid Cancer Cell Lines
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
23056499
retrieved
13 November 2016
title
AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines
(English)
1 reference
stated in
PubMed
PubMed ID
23056499
retrieved
13 November 2016
main subject
thyroid cancer
1 reference
based on heuristic
inferred from title
author name string
Joana P Couto
series ordinal
1
0 references
Ana Almeida
series ordinal
2
0 references
Laura Daly
series ordinal
3
0 references
Manuel Sobrinho-Simões
series ordinal
4
0 references
Jacqueline F Bromberg
series ordinal
5
0 references
Paula Soares
series ordinal
6
0 references
language of work or name
English
0 references
publication date
2012
0 references
published in
PLOS One
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volume
7
0 references
page(s)
e46869
0 references
issue
10
0 references
copyright license
Creative Commons Attribution 4.0 International
start time
2 October 2012
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
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MEN2A-RET-induced cellular transformation by activation of STAT3
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Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation
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The GDNF family: signalling, biological functions and therapeutic value
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20 March 2017
RET tyrosine kinase signaling in development and cancer
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Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
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Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells
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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
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S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.
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29 September 2017
Therapeutic potential of AZD1480 for the treatment of human glioblastoma
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PubMed Central
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29 September 2017
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.
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PubMed Central
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29 September 2017
How to Treat a Signal? Current Basis for RET-Genotype-Oriented Choice of Kinase Inhibitors for the Treatment of Medullary Thyroid Cancer
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Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond
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29 September 2017
The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival
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29 September 2017
Targeting RET receptor tyrosine kinase activation in cancer
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PubMed Central
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29 September 2017
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors
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PubMed Central
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29 September 2017
High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)
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In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
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29 September 2017
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines
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Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244.
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29 September 2017
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines
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29 September 2017
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
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Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.
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29 September 2017
Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation
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29 September 2017
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
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29 September 2017
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response.
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PubMed Central
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29 September 2017
RET-familial medullary thyroid carcinoma mutants Y791F and S891A activate a Src/JAK/STAT3 pathway, independent of glial cell line-derived neurotrophic factor.
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29 September 2017
Jak2 tyrosine kinase: a true jak of all trades?
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Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells
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29 September 2017
Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways
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PubMed Central
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29 September 2017
Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
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PubMed Central
reference URL
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29 September 2017
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells
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PubMed Central
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2 June 2018
Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.
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PubMed Central
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2 June 2018
Tumor measurement in the nude mouse
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PubMed Central
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2 June 2018
A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases
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2 June 2018
A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
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28 July 2018
The tight relationship between papillary thyroid cancer, autoimmunity and inflammation: clinical and molecular studies
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27 November 2018
Sulforhodamine B colorimetric assay for cytotoxicity screening.
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27 November 2018
Proinflammatory mediators and genetic background in oncogene mediated tumor progression
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27 November 2018
Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.
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27 November 2018
Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?
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27 November 2018
Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
1 reference
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27 November 2018
Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23056499
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1371/JOURNAL.PONE.0046869
0 references
ADS bibcode
2012PLoSO...746869C
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PMCID
3462763
1 reference
stated in
PubMed
PubMed ID
23056499
retrieved
13 November 2016
PubMed ID
23056499
1 reference
stated in
PubMed
PubMed ID
23056499
retrieved
13 November 2016
ResearchGate publication ID
232233088
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