(Q53414254)

14 May 2018

title

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. (English)

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14 May 2018

author name string

Segouffin-Cariou C

series ordinal

1

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14 May 2018

Billaud M

series ordinal

2

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14 May 2018

language of work or name

English

0 references

publication date

1 February 2000

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14 May 2018

Journal of Biological Chemistry

number of pages

9

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based on heuristic

inferred from page(s)

published in

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14 May 2018

volume

275

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14 May 2018

page(s)

3568-3576

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14 May 2018

issue

5

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14 May 2018

GDNF family neurotrophic factor signaling: four masters, one servant?

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Dual effect on the RET receptor of MEN 2 mutations affecting specific extracytoplasmic cysteines

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

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Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation

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A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

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Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain

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Oncogenic RET receptors display different autophosphorylation sites and substrate binding specificities

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Production of high-titer helper-free retroviruses by transient transfection

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo

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SH2 domains recognize specific phosphopeptide sequences

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

21 January 2018

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

21 January 2018

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

21 January 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

21 January 2018

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

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Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

21 January 2018

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PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.

21 January 2018

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The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

21 January 2018

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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

21 January 2018

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Akt is more than just a Bad kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.275.5.3568

21 January 2018

Identifiers

DOI

10.1074/JBC.275.5.3568

1 reference

14 May 2018

PubMed ID

10652352

1 reference

14 May 2018