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Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
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scholarly article
1 reference
stated in
PubMed
PubMed ID
23200175
retrieved
13 November 2016
title
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study
(English)
1 reference
stated in
PubMed
PubMed ID
23200175
retrieved
13 November 2016
main subject
placebo
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multicenter clinical trial
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lung cancer
1 reference
based on heuristic
inferred from title
docetaxel
1 reference
based on heuristic
inferred from title
author
Pasi A Jänne
series ordinal
1
object named as
Pasi A Jänne
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author name string
Alice T Shaw
series ordinal
2
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José Rodrigues Pereira
series ordinal
3
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Gaëlle Jeannin
series ordinal
4
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Johan Vansteenkiste
series ordinal
5
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Carlos Barrios
series ordinal
6
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Fabio Andre Franke
series ordinal
7
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Lynda Grinsted
series ordinal
8
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Victoria Zazulina
series ordinal
9
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Paul Smith
series ordinal
10
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Ian Smith
series ordinal
11
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Lucio Crinò
series ordinal
12
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publication date
January 2013
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published in
Lancet Oncology Commission
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volume
14
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page(s)
38-47
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issue
1
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cites work
Global cancer statistics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970489-8
retrieved
7 January 2021
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inferred from DOI database lookup
Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
1 reference
stated in
Crossref
reference URL
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Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
1 reference
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Crossref
reference URL
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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
1 reference
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reference URL
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Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
1 reference
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Crossref
reference URL
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The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis
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Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer
1 reference
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Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
1 reference
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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
1 reference
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reference URL
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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl
1 reference
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Crossref
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Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
1 reference
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The first-in-human study of the hydrogen sulfate (Hyd-sulfate) capsule of the MEK1/2 inhibitor AZD6244 (ARRY-142886): a phase I open-label multicenter trial in patients with advanced cancer
1 reference
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reference URL
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7 January 2021
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A phase II, open-label, randomized study to assess the efficacy and safety of AZD6244 (ARRY-142886) versus pemetrexed in patients with non-small cell lung cancer who have failed one or two prior chemotherapeutic regimens
1 reference
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Crossref
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7 January 2021
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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models
1 reference
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Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS)
1 reference
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2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
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Reliability and validity of the Functional Assessment of Cancer Therapy-Lung (FACT-L) quality of life instrument.
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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
1 reference
stated in
Crossref
reference URL
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based on heuristic
inferred from DOI database lookup
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
1 reference
stated in
Crossref
reference URL
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retrieved
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based on heuristic
inferred from DOI database lookup
Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy.
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial
1 reference
stated in
Crossref
reference URL
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Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial
1 reference
stated in
Crossref
reference URL
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A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970489-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II open-label randomized study to assess the efficacy and safety of selumetinib (AZD6244 [ARRY-142886]) versus capecitabine in patients with advanced or metastatic pancreatic cancer who have failed first-line gemcitabine therapy.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1470-2045%2812%2970489-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1470-2045(12)70489-8
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
560043
OpenCitations bibliographic resource ID
560043
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
560043
PubMed ID
23200175
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
560043
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