(Q27852093)

13 November 2016

title

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo (English)

1 reference

ORCID Public Data File 2021

PubMed

PubMed publication ID

13 November 2016

1 reference

author name string

Christian Posch

1

0 references

Homayoun Moslehi

2

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Luzviminda Feeney

3

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Gary A Green

4

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Anoosheh Ebaee

5

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Valentin Feichtenschlager

6

0 references

Kim Chong

7

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Lily Peng

8

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Michelle T Dimon

9

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Thomas Phillips

10

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Adil I Daud

11

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Timothy H McCalmont

12

0 references

Philip E LeBoit

13

0 references

Susana Ortiz-Urda

Proceedings of the National Academy of Sciences of the United States of America

14

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language of work or name

English

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publication date

5 March 2013

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published in

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volume

110

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issue

10

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page(s)

4015-20

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cites work

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1 reference

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Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors

20 March 2017

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Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase

20 March 2017

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Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

20 March 2017

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

20 March 2017

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

20 March 2017

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Hyperactive Ras in developmental disorders and cancer

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

7 April 2017

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Distinct sets of genetic alterations in melanoma

7 April 2017

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

7 April 2017

1 reference

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Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice

29 September 2017

1 reference

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A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

29 September 2017

1 reference

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Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines

29 September 2017

1 reference

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Targeting NRAS in melanoma

29 September 2017

1 reference

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Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations

29 September 2017

1 reference

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Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance.

29 September 2017

1 reference

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mTORC1 inhibition and ECM-cell adhesion-independent drug resistance via PI3K-AKT and PI3K-RAS-MAPK feedback loops

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

29 September 2017

Targeting oncogenic Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Oncogenic Ras in tumour progression and metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3593920

Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders.

29 September 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216013110

Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216013110

Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216013110

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1216013110

Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23431193

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ras mutations in human melanoma: a marker of malignant progression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23431193

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1216013110

1 reference

ADS bibcode

2013PNAS..110.4015P

0 references

1 reference

1 reference

PubMed publication ID

23431193

1 reference