(Q27853380)

English

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

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scholarly article

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PubMed publication ID

13 November 2016

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial (English)

1 reference

PubMed publication ID

13 November 2016

phase II clinical trial

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multicenter clinical trial

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colorectal cancer

1 reference

based on heuristic

inferred from title

metastatic colon cancer

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Andrea Sartore-Bianchi

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Livio Trusolino

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Francesca Bergamo

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Vittorina Zagonel

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Francesco Leone

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Ilaria Depetris

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Giulia Siravegna

15

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

16

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

17

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Angelo Vanzulli

24

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

25

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Silvio Marco Veronese

26

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Paolo M. Comoglio

27

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Alberto Bardelli

28

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

29

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Salvatore Siena

30

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Andrea Bertotti

14

object named as

Andrea Bertotti

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Katia Bencardino

4

object named as

Katia Bencardino

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

13

object named as

Patrizia Racca

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Calogero Lauricella

23

object named as

Calogero Lauricella

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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Erika Martinelli

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Teresa Troiani

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Silvia Ghezzi

18

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Giovanna Marrapese

19

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Laura Palmeri

20

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Emanuele Valtorta

21

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Andrea Cassingena

22

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Fortunato Ciardiello

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

publication date

June 2016

0 references

Lancet Oncology Commission

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

17

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

738-746

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Cancer genome landscapes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Comprehensive molecular characterization of human colon and rectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The genomic landscape of response to EGFR blockade in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Metastatic colorectal cancer: current state and future directions

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Assessment of a HER2 scoring system for colorectal cancer: results from a validation study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Sample size tables for exact single-stage phase II designs

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The meaning and use of the area under a receiver operating characteristic (ROC) curve

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Evaluating the yield of medical tests

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

An introduction to recursive partitioning: rationale, application, and characteristics of classification and regression trees, bagging, and random forests

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel CAD-ALK gene rearrangement is drugable by entrectinib in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Low overexpression of HER-2/neu in advanced colorectal cancer limits the usefulness of trastuzumab (Herceptin) and irinotecan as therapy. A phase II trial

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Marked response to single agent trastuzumab in a patient with metastatic HER-2 gene amplified rectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A 21-year-old patient with a HER2-positive colorectal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Randomized trial of TAS-102 for refractory metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

High HER2 expression correlates with response to the combination of lapatinib and trastuzumab.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Biomarkers of drugs targeting HER-family signalling in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2816%2900150-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1470-2045(16)00150-9

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27108243%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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