(Q27863350)

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5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

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15 November 2016

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity (English)

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15 November 2016

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3

Tomas Lindahl

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author name string

Qian An

series ordinal

1

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Peter Robins

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2

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Deborah E Barnes

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4

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language of work or name

English

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publication date

1 February 2007

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67

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page(s)

940-5

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issue

3

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cites work

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

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Interactions between deoxyribonucleotide and DNA synthesis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs

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Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

5-Fluorodeoxyuridine as an alternative to the synthesis of mixed hybridization probes for the detection of specific gene sequences

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

DNA base excision repair of uracil residues in reconstituted nucleosome core particles

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1

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11 October 2022

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Linking uracil base excision repair and 5-fluorouracil toxicity in yeast

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Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

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11 October 2022

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5-Fluorouracil: mechanisms of action and clinical strategies

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.

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11 October 2022

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C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases

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11 October 2022

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Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1158/0008-5472.CAN-06-2960

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DOI

10.1158/0008-5472.CAN-06-2960

1 reference

15 November 2016

1 reference

15 November 2016

(Q27863350)

5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity

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