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Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
20462952
retrieved
1 December 2016
title
Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins
(English)
1 reference
stated in
PubMed
PubMed ID
20462952
retrieved
1 December 2016
main subject
cell biology
0 references
quality control
0 references
E2 ubiquitin-conjugating protein UBC4 YBR082C
1 reference
stated in
GOA release 2020-03-11
Hsp70 family ATPase SSA1 YAL005C
1 reference
stated in
GOA release 2020-03-11
E2 ubiquitin-conjugating protein RAD6 YGL058W
1 reference
stated in
GOA release 2020-03-11
Putative ubiquitin-protein ligase UBR2 YLR024C
1 reference
stated in
GOA release 2020-03-11
E3 ubiquitin-protein ligase UBR1 YGR184C
1 reference
stated in
GOA release 2020-03-11
author name string
Rasheda Sultana
series ordinal
6
0 references
Nadinath B Nillegoda
series ordinal
1
0 references
Maria A Theodoraki
series ordinal
2
0 references
Kenneth Wu
series ordinal
7
0 references
Katie J Mayo
series ordinal
4
0 references
Jill Johnson
series ordinal
8
0 references
Hong Yu Ren
series ordinal
5
0 references
Douglas M Cyr
series ordinal
9
0 references
Avrom J Caplan
series ordinal
10
0 references
Atin K Mandal
series ordinal
3
0 references
language of work or name
English
0 references
publication date
1 July 2010
0 references
published in
Molecular Biology of the Cell
1 reference
stated in
PubMed
PubMed ID
20462952
retrieved
1 December 2016
volume
21
0 references
page(s)
2102-16
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issue
13
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cites work
Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
One step at a time: endoplasmic reticulum-associated degradation
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PubMed Central
reference URL
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20 March 2017
Misfolded proteins partition between two distinct quality control compartments
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
Dissecting the ER-associated degradation of a misfolded polytopic membrane protein
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PubMed Central
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20 March 2017
Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation
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PubMed Central
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20 March 2017
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
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PubMed Central
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20 March 2017
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons
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PubMed Central
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20 March 2017
Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein
1 reference
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PubMed Central
reference URL
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20 March 2017
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
1 reference
stated in
PubMed Central
reference URL
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20 March 2017
The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain
1 reference
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PubMed Central
reference URL
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20 March 2017
The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
Identification of a family of closely related human ubiquitin conjugating enzymes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
Cooperation of the molecular chaperone Ydj1 with specific Hsp70 homologs to suppress protein aggregation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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20 March 2017
The recognition component of the N-end rule pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
20 March 2017
Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
20 March 2017
Inhibition of the N-end rule pathway in living cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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Adapting proteostasis for disease intervention
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PubMed Central
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20 March 2017
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha
1 reference
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PubMed Central
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20 March 2017
HSP90 and the chaperoning of cancer
1 reference
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PubMed Central
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7 April 2017
Pathways of chaperone-mediated protein folding in the cytosol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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7 April 2017
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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7 April 2017
Farnesylation of Ydj1 is required for in vivo interaction with Hsp90 client proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
PCNA modifications for regulation of post-replication repair pathways
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Multiple kinases and system robustness: a link between Cdc37 and genome integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
To be, or not to be--molecular chaperones in protein degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Molecular chaperones and protein kinase quality control.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Protein synthesis upon acute nutrient restriction relies on proteasome function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
A nonconserved Ala401 in the yeast Rsp5 ubiquitin ligase is involved in degradation of Gap1 permease and stress-induced abnormal proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Protein misfolding and temperature up-shift cause G1 arrest via a common mechanism dependent on heat shock factor in Saccharomycescerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Posttranslational quality control: folding, refolding, and degrading proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Degradation signals in the lysine-asparagine sequence space
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
The Hsc66-Hsc20 chaperone system in Escherichia coli: chaperone activity and interactions with the DnaK-DnaJ-grpE system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
29 September 2017
DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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29 September 2017
Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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2 June 2018
Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
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2 June 2018
Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
27 November 2018
UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
27 November 2018
Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
27 November 2018
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2893976
retrieved
27 November 2018
The effect of the l-azetidine-2-carboxylic acid residue on protein conformation. IV. Local substitutions in the collagen triple helix
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20462952
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20462952
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The DRiP hypothesis decennial: support, controversy, refinement and extension
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20462952
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1091/MBC.E10-02-0098
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2076325
OpenCitations bibliographic resource ID
2076325
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2076325
PMCID
2893976
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2076325
PubMed ID
20462952
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2076325
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