(Q27936100)

23974112

1 December 2016

title

SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation (English)

1 reference

PubMed

Gene Ontology release 2020-05-02

1 December 2016

0 references

1 reference

Gene Ontology ID

GO:1990130

Seh1-associated complex

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0035859

GTPase-activating protein IML1 YJR138W

1 reference

GOA release 2020-03-11

Seh1p YGL100W

1 reference

GTPase-activating protein SEC13 YLR208W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Claudio De Virgilio

series ordinal

3

0 references

author name string

Nicolas Panchaud

series ordinal

1

0 references

Marie-Pierre Péli-Gulli

series ordinal

2

0 references

language of work or name

English

0 references

publication date

15 September 2013

0 references

1 reference

23974112

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

1 December 2016

volume

12

0 references

issue

18

0 references

page(s)

2948-52

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1.

20 March 2017

1 reference

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Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II

20 March 2017

1 reference

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Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the ego complex to activate TORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

20 March 2017

1 reference

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Amino acids and mTORC1: from lysosomes to disease

20 March 2017

1 reference

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Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

20 March 2017

1 reference

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Leucyl-tRNA synthetase controls TORC1 via the EGO complex

20 March 2017

1 reference

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Leucine and mTORC1: a complex relationship

20 March 2017

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Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

20 March 2017

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A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae

20 March 2017

1 reference

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mTOR: from growth signal integration to cancer, diabetes and ageing

20 March 2017

1 reference

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Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals

20 March 2017

1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 March 2017

1 reference

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The Vam6 GEF controls TORC1 by activating the EGO complex

20 March 2017

1 reference

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A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex

20 March 2017

1 reference

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast

20 March 2017

1 reference

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The TOR and EGO protein complexes orchestrate microautophagy in yeast

20 March 2017

1 reference

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TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling

20 March 2017

1 reference

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Human Vam6p promotes lysosome clustering and fusion in vivo

20 March 2017

1 reference

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Regulation of TORC1 by Rag GTPases in nutrient response

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Changes in cell morphology are coordinated with cell growth through the TORC1 pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Amino acid signalling upstream of mTOR

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

COPII and the regulation of protein sorting in mammals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

The essence of yeast quiescence

29 September 2017

1 reference

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The structure of the nuclear pore complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Regulation of mTORC1 by the Rab and Arf GTPases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

The late endosome is essential for mTORC1 signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

TOR signaling in invertebrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Cell growth control: little eukaryotes make big contributions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

The COPII cage: unifying principles of vesicle coat assembly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

The TOR signalling network from yeast to man.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Glutaminolysis feeds mTORC1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

mTORC1 signals from late endosomes: taking a TOR of the endocytic system

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

An EGOcentric view of TORC1 signaling.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875668

RAG GTPases in nutrient-mediated TOR signaling pathway

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCC.26000

Glutaminolysis activates Rag-mTORC1 signaling.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCC.26000

The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4161%2FCC.26000

21 January 2018

Identifiers

DOI

10.4161/CC.26000

1 reference

1 reference

1 reference

23974112

1 reference