(Q28080674)

title

The case for inhibiting p38 mitogen-activated protein kinase in heart failure (English)

1 reference

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Pelin Arabacilar

series ordinal

1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

1 reference

12 May 2015

1 reference

Frontiers in Pharmacology

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

102

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

p38 MAPK in cardioprotection - are we there yet?

12 June 2020

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MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart

29 September 2017

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p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

29 September 2017

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Markers of autophagy are downregulated in failing human heart after mechanical unloading

29 September 2017

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Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells

29 September 2017

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Autophagy is an adaptive response in desmin-related cardiomyopathy

29 September 2017

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The intracellular renin-angiotensin system: implications in cardiovascular remodeling

29 September 2017

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Activation of immune and inflammatory systems in chronic heart failure: novel therapeutic approaches.

29 September 2017

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TNF-alpha inhibitors and congestive heart failure

29 September 2017

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Targeted anticytokine therapy and the failing heart

29 September 2017

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p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

29 September 2017

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Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

29 September 2017

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Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

29 September 2017

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29 September 2017

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Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

29 September 2017

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Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models

29 September 2017

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Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

29 September 2017

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Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy

29 September 2017

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Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1.

29 September 2017

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The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

29 September 2017

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29 September 2017

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p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes

29 September 2017

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Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium

29 September 2017

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Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation

29 September 2017

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The role of tumor necrosis factor in the pathophysiology of heart failure

29 September 2017

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Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion

29 September 2017

1 reference

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Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy

29 September 2017

1 reference

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Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

29 September 2017

1 reference

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Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation

29 September 2017

1 reference

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Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4428223

alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response

2 June 2018

1 reference

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p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system

2 June 2018

1 reference

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An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia

2 June 2018

1 reference

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Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytes

2 June 2018

1 reference

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The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT.

2 June 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Myostatin induces interstitial fibrosis in the heart via TAK1 and p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Increased collagen deposition and diastolic dysfunction but preserved myocardial hypertrophy after pressure overload in mice lacking PKCepsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

p38 alpha mitogen-activated protein kinase inhibition improves cardiac function and reduces myocardial damage in isoproterenol-induced acute myocardial injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Vascular endothelial dysfunction and superoxide anion production in heart failure are p38 MAP kinase-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

p38-MAPK Induced Dephosphorylation of α-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHAR.2015.00102

MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes

21 January 2018

1 reference

12 December 2020

p38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes

1 reference

12 December 2020

Cardiomyocyte hypertrophy, oncosis, and autophagic vacuolization predict mortality in idiopathic dilated cardiomyopathy with advanced heart failure

1 reference

12 December 2020

Hydrogen peroxide induces tumor necrosis factor alpha-mediated cardiac injury by a P38 mitogen-activated protein kinase-dependent mechanism

1 reference

12 December 2020

Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms

1 reference

12 December 2020

Elevated circulating levels of tumor necrosis factor in severe chronic heart failure

1 reference

12 December 2020

Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia

1 reference

12 December 2020

Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart

1 reference

12 December 2020

p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat

1 reference

12 December 2020

p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activation

1 reference

12 December 2020

Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart

1 reference

12 December 2020

Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases

1 reference

12 December 2020

Pressure overload hypertrophy and congestive heart failure. Where is the "Achilles' heel"?

1 reference

12 December 2020

Effects of p38 MAPK Inhibitor on angiotensin II-dependent hypertension, organ damage, and superoxide anion production

1 reference

12 December 2020

TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice.

1 reference

12 December 2020

p38 mitogen-activated protein kinase: a future target for heart failure therapy?

1 reference

12 December 2020

Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death

1 reference

12 December 2020

Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor

1 reference

12 December 2020

Tumor necrosis factor-alpha provokes a hypertrophic growth response in adult cardiac myocytes

1 reference

12 December 2020

Regulation of TNF mediated antiapoptotic signaling in human neutrophils: role of delta-PKC and ERK1/2

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHAR.2015.00102

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26029107

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26029107%20AND%20SRC:MED&resulttype=core&format=json