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Systems biology of polycystic kidney disease: a critical review
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scholarly article
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review article
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Europe PubMed Central
title
Systems biology of polycystic kidney disease: a critical review
(English)
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PubMed
main subject
polycystic kidney disease
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inferred from title
author name string
Luis Fernando Menezes
series ordinal
1
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Gregory G. Germino
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2
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language of work or name
English
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publication date
2015
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published in
Wiley interdisciplinary reviews. Systems biology and medicine
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volume
7
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PubMed
issue
1
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PubMed
page(s)
39-52
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PubMed
cites work
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20 March 2017
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20 March 2017
Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study
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20 March 2017
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors
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20 March 2017
Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease
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20 March 2017
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
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7 April 2017
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
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PubMed Central
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7 April 2017
Expanding horizons: ciliary proteins reach beyond cilia
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29 September 2017
Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat.
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29 September 2017
Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.
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PubMed Central
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29 September 2017
Parallel analysis of mRNA and microRNA microarray profiles to explore functional regulatory patterns in polycystic kidney disease: using PKD/Mhm rat model
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PubMed Central
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29 September 2017
Urine proteome of autosomal dominant polycystic kidney disease patients
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.
1 reference
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PubMed Central
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29 September 2017
Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling
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PubMed Central
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29 September 2017
The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid
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PubMed Central
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29 September 2017
Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients
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PubMed Central
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29 September 2017
Polycystic kidney disease, cilia, and planar polarity.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation
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PubMed Central
reference URL
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29 September 2017
Diagnosis and screening of autosomal dominant polycystic kidney disease
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PubMed Central
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29 September 2017
Molecular advances in autosomal dominant polycystic kidney disease
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PubMed Central
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29 September 2017
A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease
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PubMed Central
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29 September 2017
Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks
1 reference
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PubMed Central
reference URL
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29 September 2017
Characterization of PKD protein-positive exosome-like vesicles
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PubMed Central
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29 September 2017
Gene expression in early and progression phases of autosomal dominant polycystic kidney disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptor
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling
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PubMed Central
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29 September 2017
A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Gene regulatory network analysis in sea urchin embryos.
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PubMed Central
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29 September 2017
New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Beta4 integrin and laminin 5 are aberrantly expressed in polycystic kidney disease: role in increased cell adhesion and migration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
The polycystic kidney disease 1 gene product modulates Wnt signaling
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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29 September 2017
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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2 June 2018
Protein composition of liver cyst fluid from the BALB/c-cpk/+ mouse model of autosomal recessive polycystic kidney disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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2 June 2018
Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.
1 reference
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PubMed Central
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2 June 2018
The robustness and evolvability of transcription factor binding sites.
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27 November 2018
Scientific method: statistical errors
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PubMed Central
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27 November 2018
Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany
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PubMed Central
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27 November 2018
Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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27 November 2018
Validation of gene regulatory networks: scientific and inferential.
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27 November 2018
Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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27 November 2018
Gene profiling of polycystic kidneys.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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27 November 2018
A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339620
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27 November 2018
The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.
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PubMed Central
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27 November 2018
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Popper, laws, and the exclusion of biology from genuine science
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
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Transcriptome analysis of a rat PKD model: Importance of genes involved in extracellular matrix metabolism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of specific genes activating RAGE on polycystic kidney disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of phosphoproteins in kidney tissues from patients with autosomal dominant polycystic kidney disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25641951
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1002/WSBM.1289
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PMC publication ID
4339620
1 reference
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PubMed
PubMed publication ID
25641951
1 reference
stated in
PubMed
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