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Targeting CDK4 and CDK6: From Discovery to Therapy
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title
Targeting CDK4 and CDK6: From Discovery to Therapy
(English)
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PubMed
author name string
C. J. Sherr
series ordinal
1
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D. Beach
series ordinal
2
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G. I. Shapiro
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3
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language of work or name
English
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publication date
April 2016
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PubMed
published in
Cancer Discovery
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PubMed
volume
6
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PubMed
issue
4
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PubMed
page(s)
353-67
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PubMed
cites work
The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study
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PubMed Central
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Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
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Requirement for CDK4 kinase function in breast cancer
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Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase
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Sibling rivalry in the E2F family
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D-type cyclin-dependent kinase activity in mammalian cells
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Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
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Selective impact of CDK4/6 suppression on patient-derived models of pancreatic cancer
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Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
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Forging a signature of in vivo senescence
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Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer
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Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment
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MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.
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CDK 4/6 inhibitor palbociclib (PD0332991) in Rb+ advanced breast cancer: phase II activity, safety, and predictive biomarker assessment
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CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer
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Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma
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Antiproliferative effects of CDK4/6 inhibition in CDK4-amplified human liposarcoma in vitro and in vivo
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29 September 2017
CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers
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29 September 2017
Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine
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29 September 2017
Semi-mechanistic pharmacokinetic/pharmacodynamic modeling of the antitumor activity of LY2835219, a new cyclin-dependent kinase 4/6 inhibitor, in mice bearing human tumor xenografts
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29 September 2017
Molecular pathways: CDK4 inhibitors for cancer therapy
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29 September 2017
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29 September 2017
Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.
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29 September 2017
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.
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Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
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29 September 2017
Aging, cellular senescence, and cancer
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Phase I study of PD 0332991, a cyclin-dependent kinase inhibitor, administered in 3-week cycles (Schedule 2/1).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Cellular mechanisms of tumour suppression by the retinoblastoma gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Relevance of the concept of oncogene addiction to hormonal carcinogenesis and molecular targeting in cancer prevention and therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
p16INK4a induces an age-dependent decline in islet regenerative potential
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Living with or without cyclins and cyclin-dependent kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Development of mice expressing a single D-type cyclin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Specific protection against breast cancers by cyclin D1 ablation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
CDK4 expression and activity are required for cytokine responsiveness in T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Small GTPases and cell cycle regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Relationship between Ras pathways and cell cycle control.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Cyclin D1 overexpression in non-Hodgkin's lymphoma with chromosome 11 bcl-1 rearrangement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Novel mammalian cyclins (CYL genes) expressed during G1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
Animal cell cycles and their control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
29 September 2017
PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
2 June 2018
The cancer drug that almost wasn't.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Simultaneous inhibition of MEK and CDK4 leads to potent apoptosis in human melanoma cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Treatment of growing teratoma syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Mouse development and cell proliferation in the absence of D-cyclins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4821753
retrieved
27 November 2018
Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Formation of p27-CDK complexes during the human mitotic cell cycle
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Toward an understanding of the functional complexity of the E2F and retinoblastoma families
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26658964
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/2159-8290.CD-15-0894
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
577376
OpenCitations bibliographic resource ID
577376
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
577376
PMC publication ID
4821753
1 reference
stated in
PubMed
PubMed publication ID
26658964
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
577376
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