(Q28188558)

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HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors

scientific article (publication date: 11 July 2003)

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Europe PubMed Central

HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors (English)

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membrane fusion involved in viral entry into host cell

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author name string

Marina Zaitseva

1

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Keith Peden

2

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Hana Golding

3

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language of work or name

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publication date

11 July 2003

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Biochimica et Biophysica Acta

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1614

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1

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51-61

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

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7 January 2021

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

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7 January 2021

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7 January 2021

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

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7 January 2021

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

1 reference

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7 January 2021

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

1 reference

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7 January 2021

Identification of a major co-receptor for primary isolates of HIV-1

1 reference

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7 January 2021

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

1 reference

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7 January 2021

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1 reference

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7 January 2021

Coreceptors for human immunodeficiency virus and simian immunodeficiency virus

1 reference

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7 January 2021

Introduction: HIV co-receptors solve old questions and raise many new ones

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7 January 2021

The antigenic structure of the HIV gp120 envelope glycoprotein

1 reference

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7 January 2021

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1 reference

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7 January 2021

N-linked glycosylation of CXCR4 masks coreceptor function for CCR5-dependent human immunodeficiency virus type 1 isolates

1 reference

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7 January 2021

Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1.

1 reference

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7 January 2021

Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry

1 reference

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7 January 2021

Evidence for common structural determinants of human immunodeficiency virus type 1 coreceptor activity provided through functional analysis of CCR5/CXCR4 chimeric coreceptors

1 reference

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7 January 2021

Mechanisms of viral membrane fusion and its inhibition

1 reference

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7 January 2021

Dissection of human immunodeficiency virus type 1 entry with neutralizing antibodies to gp41 fusion intermediates

1 reference

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7 January 2021

Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Capture of an early fusion-active conformation of HIV-1 gp41

1 reference

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7 January 2021

Peptides corresponding to the heptad repeat motifs in the transmembrane protein (gp41) of human immunodeficiency virus type 1 elicit antibodies to receptor-activated conformations of the envelope glycoprotein

1 reference

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7 January 2021

Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites

1 reference

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7 January 2021

Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines

1 reference

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7 January 2021

CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

1 reference

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7 January 2021

Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Constitutive cell surface association between CD4 and CCR5.

1 reference

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7 January 2021

Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells

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Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1

1 reference

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7 January 2021

Evidence for CD4-enchanced signaling through the chemokine receptor CCR5

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7 January 2021

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

1 reference

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7 January 2021

Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor

1 reference

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7 January 2021

Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity

1 reference

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7 January 2021

Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines

1 reference

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7 January 2021

Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry

1 reference

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7 January 2021

A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry

1 reference

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7 January 2021

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

1 reference

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7 January 2021

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

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7 January 2021

Linking cargo to vesicle formation: receptor tail interactions with coat proteins.

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7 January 2021

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The structural era of endocytosis

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7 January 2021

Downregulation of G protein-coupled receptors

1 reference

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7 January 2021

Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4.

1 reference

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7 January 2021

Endocytosis and recycling of the HIV coreceptor CCR5

1 reference

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7 January 2021

Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection

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7 January 2021

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

1 reference

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7 January 2021

Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization

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Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting

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7 January 2021

Ligand-induced desensitization of the human CXC chemokine receptor-2 is modulated by multiple serine residues in the carboxyl-terminal domain of the receptor

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7 January 2021

Chemokine-induced phosphorylation of CC chemokine receptor 5 (CCR5).

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization

1 reference

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7 January 2021

Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus

1 reference

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7 January 2021

Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies

1 reference

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7 January 2021

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

1 reference

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7 January 2021

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

1 reference

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7 January 2021

Human immunodeficiency virus type 1 IIIB selected for replication in vivo exhibits increased envelope glycoproteins in virions without alteration in coreceptor usage: separation of in vivo replication from macrophage tropism

1 reference

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7 January 2021

Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.

1 reference

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7 January 2021

Calcium-stimulated phosphorylation of MAP-2 in pancreatic betaTC3-cells is mediated by Ca2+/calmodulin-dependent kinase II

1 reference

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7 January 2021

SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways

1 reference

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7 January 2021

Chemokines and HIV-1 second receptors: the therapeutic connection

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7 January 2021

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1 reference

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7 January 2021

HIV blocked by chemokine antagonist

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

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7 January 2021

Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: dissociation from CCR5 activation

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Inhibition of HIV type 1 infection with a RANTES-IgG3 fusion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Aminooxypentane addition to the chemokine macrophage inflammatory protein-1alpha P increases receptor affinities and HIV inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Mechanisms involved in stimulation of human immunodeficiency virus type 1 replication by aminooxypentane RANTES.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection: in vitro studies of mixed virus infections.

1 reference

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7 January 2021

Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

The inhibitory effect of RANTES on the infection of primary macrophages by R5 human immunodeficiency virus type-1 depends on the macrophage activation state

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

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7 January 2021

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

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7 January 2021

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

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7 January 2021

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

1 reference

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7 January 2021

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

1 reference

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7 January 2021

A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Structure-activity relationships of an anti-HIV peptide, T22.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Attachment of C-terminus of SDF-1 enhances the biological activity of its N-terminal peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Inactivation of HIV-1 chemokine co-receptor CXCR-4 by a novel intrakine strategy

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Phenotypic knockout of HIV type 1 chemokine coreceptor CCR-5 by intrakines as potential therapeutic approach for HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Anti-HIV type 1 activity of wild-type and functional defective RANTES intrakine in primary human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

The role of CC chemokine receptor 5 in antiviral immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Stromal-derived factor 1 expression in the human thymus

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Structural interactions between chemokine receptors, gp120 Env and CD4

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Molecular modeling and site-directed mutagenesis of CCR5 reveal residues critical for chemokine binding and signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Structure-function studies of the HIV-1 coreceptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

CD4-independent use of Rhesus CCR5 by human immunodeficiency virus Type 2 implicates an electrostatic interaction between the CCR5 N terminus and the gp120 C4 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

A replication-competent, neutralization-sensitive variant of simian immunodeficiency virus lacking 100 amino acids of envelope

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Entry of R5X4 and X4 human immunodeficiency virus type 1 strains is mediated by negatively charged and tyrosine residues in the amino-terminal domain and the second extracellular loop of CXCR4.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Structural and functional characterization of human CXCR4 as a chemokine receptor and HIV-1 co-receptor by mutagenesis and molecular modeling studies

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4-negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2803%2900162-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0005-2736(03)00162-7

0 references

release_hvowgpwul5b4zoytitvncfzmve

1 reference

https://api.fatcat.wiki/v0/release/hvowgpwul5b4zoytitvncfzmve

24 November 2022

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q28188558&oldid=1835788190"