(Q28190760)

12 December 2020

Characterization of the role of the "MT-loop": an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases

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12 December 2020

Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor

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12 December 2020

Structure of human neutrophil collagenase reveals large S1' specificity pocket

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12 December 2020

Collagenolytic activity in amphibian tissues: a tissue culture assay

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12 December 2020

The NMR structure of the inhibited catalytic domain of human stromelysin-1

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12 December 2020

Structure of recombinant mouse collagenase-3 (MMP-13)

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12 December 2020

Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study

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12 December 2020

Matrix metalloproteinase inhibition and the prevention of heart failure

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12 December 2020

Matrix metalloproteinases: a tail of a frog that became a prince

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12 December 2020

Activation mechanisms of matrix metalloproteinases.

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12 December 2020

On the size of the active site in proteases. I. Papain

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12 December 2020

Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif

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12 December 2020

Relating matrix metalloproteinase structure to function: why the "hemopexin" domain?

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12 December 2020

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

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12 December 2020

Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase

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12 December 2020

Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

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12 December 2020

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor

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12 December 2020

Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis

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12 December 2020

The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity

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12 December 2020

Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor

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12 December 2020

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

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12 December 2020

Gelatinase B: a tuner and amplifier of immune functions.

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12 December 2020

Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme

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12 December 2020

Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family

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12 December 2020

The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations

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12 December 2020

Structure of astacin with a transition-state analogue inhibitor

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12 December 2020

Roles of the propeptide and metal ions in the folding and stability of the catalytic domain of stromelysin (matrix metalloproteinase 3).

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12 December 2020

Tissue inhibitors of matrix metalloendopeptidases

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12 December 2020

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller

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12 December 2020

The conserved methionine residue of the metzincins: a site-directed mutagenesis study

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12 December 2020

Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor

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12 December 2020

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

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12 December 2020

NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases

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12 December 2020

MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors

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12 December 2020

Matrix metalloproteinases

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12 December 2020

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

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12 December 2020

Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3

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12 December 2020

Matrix metalloproteinase inhibitors in arthritis.

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12 December 2020

Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.

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12 December 2020

Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members

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12 December 2020

Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.

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12 December 2020

A matrix metalloproteinase expressed on the surface of invasive tumour cells

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12 December 2020

Tissue inhibitors of metalloproteinases: evolution, structure and function

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12 December 2020

Solution structure of a type 2 module from fibronectin: implications for the structure and function of the gelatin-binding domain

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12 December 2020

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily

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12 December 2020

ALSCRIPT: a tool to format multiple sequence alignments

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12 December 2020

Structural studies on MMPs and TIMPs.

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12 December 2020

Matrix metalloproteinases in tumor invasion

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12 December 2020

Matrix metalloproteinase substrate binding domains, modules and exosites. Overview and experimental strategies.

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12 December 2020

Development of matrix metalloproteinase inhibitors in cancer therapy.

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12 December 2020

High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3

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12 December 2020

The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study

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12 December 2020

Structural basis of the adaptive molecular recognition by MMP9

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12 December 2020

Preclinical development of metalloproteasis inhibitors in cancer therapy.

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12 December 2020

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family

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12 December 2020

Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases

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12 December 2020

Matrix metalloproteinases in lung biology

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12 December 2020

Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.

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12 December 2020

Crystal structure of human MMP9 in complex with a reverse hydroxamate inhibitor

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12 December 2020

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'

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12 December 2020

Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.

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12 December 2020

The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases

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12 December 2020

Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself

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12 December 2020

Computational sequence analysis of matrix metalloproteinases.

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12 December 2020

Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases

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12 December 2020

Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in brea

1 reference

12 December 2020

Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)

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12 December 2020

Crystal structure of a complex between Pseudomonas aeruginosa alkaline protease and its cognate inhibitor: inhibition by a zinc-NH2 coordinative bond

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12 December 2020

A helping hand for collagenases: the haemopexin-like domain

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12 December 2020

Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases

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12 December 2020

Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor

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12 December 2020

Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate

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12 December 2020

CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch.

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12 December 2020

SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

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12 December 2020

The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity

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12 December 2020

Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed

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12 December 2020

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

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12 December 2020

Mutational study of the amino-terminal domain of human tissue inhibitor of metalloproteinases 1 (TIMP-1) locates an inhibitory region for matrix metalloproteinases

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12 December 2020

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells

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12 December 2020

Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.

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12 December 2020

Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors

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12 December 2020

Crystal structure of the haemopexin-like C-terminal domain of gelatinase A

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12 December 2020

Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway

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12 December 2020

Matrilysin-inhibitor complexes: common themes among metalloproteases

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12 December 2020

Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury

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12 December 2020

How matrix metalloproteinases regulate cell behavior

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12 December 2020

Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

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12 December 2020

Mutational analysis of residues in and around the active site of human fibroblast-type collagenase

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12 December 2020

1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin

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12 December 2020

Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases

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12 December 2020

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition

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12 December 2020

The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain

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12 December 2020

Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure

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12 December 2020

Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase

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12 December 2020

Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-terminal domains of gelatinases A and B. Regulation by polyanions

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12 December 2020

Raster3D: photorealistic molecular graphics

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12 December 2020

Matrix metalloproteinases: structures, evolution, and diversification

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12 December 2020

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention

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12 December 2020

Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis

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12 December 2020

Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a single cleavage for both secretion and activation

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12 December 2020

Identification of the (183)RWTNNFREY(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity

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12 December 2020

Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity

1 reference

12 December 2020

1.56 A structure of mature truncated human fibroblast collagenase

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12 December 2020

The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function

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12 December 2020

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1 reference

12 December 2020

Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.

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12 December 2020

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

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12 December 2020

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2.

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12 December 2020

Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network

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12 December 2020

Human endothelial gelatinases and angiogenesis

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12 December 2020

Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain.

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12 December 2020

Matrix metalloproteinases

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12 December 2020

Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase

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12 December 2020

Matrix metalloproteinases: multifunctional contributors to tumor progression

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12 December 2020

Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

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12 December 2020

Mutation of the active site glutamic acid of human gelatinase A: effects on latency, catalysis, and the binding of tissue inhibitor of metalloproteinases-1.

1 reference

12 December 2020

Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases

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12 December 2020

Proteolysis and cell migration: creating a path?

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12 December 2020

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

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12 December 2020

Interstitial collagenases as markers of tumor progression

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12 December 2020

MMP inhibitors: glimmers of hope amidst clinical failures.

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12 December 2020

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

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12 December 2020

Matrix metalloproteinases in tumor invasion and metastasis

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12 December 2020

Computational sequence analysis of the tissue inhibitor of metalloproteinase family

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12 December 2020

Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis

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12 December 2020

Mapping the binding site for matrix metalloproteinase on the N-terminal domain of the tissue inhibitor of metalloproteinases-2 by NMR chemical shift perturbation

1 reference

12 December 2020

Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation

1 reference

12 December 2020

X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design

1 reference

12 December 2020

Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct

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12 December 2020

The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation

1 reference

12 December 2020

Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state

1 reference

12 December 2020