(Q28208482)

2

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R D Mashal

3

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K P Wilson

4

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M S Su

5

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M A Murcko

Current Opinion in Chemical Biology

6

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language of work or name

English

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publication date

August 2001

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published in

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volume

5

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issue

4

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page(s)

464-70

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cites work

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The role of innovation in drug development

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Chemical genetics resulting from a passion for synthetic organic chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Drug discovery in the next millennium

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Forecasting roles of combinatorial chemistry in the age of genomically derived drug discovery targets

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The impact of genomics on drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Molecular basis for p38 protein kinase inhibitor specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The gating mechanism of the large mechanosensitive channel MscL

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

ATP site-directed competitive and irreversible inhibitors of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The development and therapeutic potential of protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Regulation of transcription by MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Recent advances on neuronal caspases in development and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Virtual screening—an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Designing libraries with CNS activity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The properties of known drugs. 1. Molecular frameworks

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Properties of known drugs. 2. Side chains

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Nuclear magnetic resonance-based approaches for lead generation in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021

Drug discovery: a historical perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900229-5

7 January 2021