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Chemogenomic approaches to drug discovery
scientific article (publication date: August 2001)
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instance of
scholarly article
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review article
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stated in
Europe PubMed Central
title
Chemogenomic approaches to drug discovery
(English)
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main subject
drug discovery
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author name string
P R Caron
series ordinal
1
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M D Mullican
series ordinal
2
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R D Mashal
series ordinal
3
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K P Wilson
series ordinal
4
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M S Su
series ordinal
5
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M A Murcko
series ordinal
6
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language of work or name
English
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publication date
August 2001
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published in
Current Opinion in Chemical Biology
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volume
5
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page(s)
464-70
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issue
4
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cites work
Initial sequencing and analysis of the human genome
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The Sequence of the Human Genome
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The role of innovation in drug development
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Chemical genetics resulting from a passion for synthetic organic chemistry.
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Drug discovery in the next millennium
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Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era
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Forecasting roles of combinatorial chemistry in the age of genomically derived drug discovery targets
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The impact of genomics on drug discovery
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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
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Molecular basis for p38 protein kinase inhibitor specificity
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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.
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Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes
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Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance
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The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
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Crystal structure of rhodopsin: A G protein-coupled receptor
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The gating mechanism of the large mechanosensitive channel MscL
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ATP site-directed competitive and irreversible inhibitors of protein kinases
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The development and therapeutic potential of protein kinase inhibitors
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Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine
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Regulation of transcription by MAP kinase cascades
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7 January 2021
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Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme
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Recent advances on neuronal caspases in development and neurodegeneration
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The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
1 reference
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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Virtual screening—an overview
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Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?
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Designing libraries with CNS activity
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7 January 2021
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The properties of known drugs. 1. Molecular frameworks
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7 January 2021
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Properties of known drugs. 2. Side chains
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7 January 2021
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Consensus scoring: A method for obtaining improved hit rates from docking databases of three-dimensional structures into proteins.
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The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.
1 reference
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Nuclear magnetic resonance-based approaches for lead generation in drug discovery.
1 reference
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Drug discovery: a historical perspective
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7 January 2021
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Identifiers
DOI
10.1016/S1367-5931(00)00229-5
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PubMed ID
11470611
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