(Q28214002)

1

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Ola Samulesson

2

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Peter Währborg

3

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Hans Wadenvik

4

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Kjell-Arne Ung

https://scigraph.springernature.com/pub.10.2165/00003495-200464200-00004

5

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language of work or name

English

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publication date

2004

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published in

Drugs

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volume

64

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page(s)

2315-43; discussion 2344-5

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issue

20

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exact match

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cites work

Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries

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12 December 2020

Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide

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12 December 2020

Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent.

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12 December 2020

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

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12 December 2020

Cyclooxygenase 2 and wound healing in the stomach

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12 December 2020

Selective inhibitors of cyclooxygenase-2: are they really effective, selective, and GI-safe?

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12 December 2020

Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed?

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12 December 2020

Increased Prostacyclin Biosynthesis in Patients with Severe Atherosclerosis and Platelet Activation

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12 December 2020

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

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12 December 2020

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

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12 December 2020

Nabumetone: a single-center three-week comparison with placebo in the treatment of rheumatoid arthritis.

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12 December 2020

Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients

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12 December 2020

Nitric oxide: a regulator of mucosal defense and injury

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12 December 2020

Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in the elderly

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12 December 2020

Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects

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12 December 2020

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

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12 December 2020

Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis

1 reference

12 December 2020

Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man

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12 December 2020

Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2

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12 December 2020

Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis

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12 December 2020

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

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12 December 2020

Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: implication for renal function.

1 reference

12 December 2020

Aspirin as an antiplatelet drug

1 reference

12 December 2020

Safety profiles of leading nonsteroidal anti-inflammatory drugs.

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12 December 2020

Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.

1 reference

12 December 2020

Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group.

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12 December 2020

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

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12 December 2020

Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation

1 reference

12 December 2020

Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug-associated gastropathy: incidence and risk factor models

1 reference

12 December 2020

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1 reference

12 December 2020

Innovative treatment approaches for rheumatoid arthritis. New cyclo-oxygenase and cytokine inhibitors

1 reference

12 December 2020

Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease, or treatment?

1 reference

12 December 2020

Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance

1 reference

12 December 2020

Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development

1 reference

12 December 2020

Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis

1 reference

12 December 2020

Metabolism of nabumetone (BRL 14777) by various species including man

1 reference

12 December 2020

Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells

1 reference

12 December 2020

Comparison of the safety and efficacy of nabumetone and aspirin in the treatment of osteoarthritis in adults

1 reference

12 December 2020

Failure of Intravenous Aspirin to Increase Gastrointestinal Blood Loss

1 reference

12 December 2020

Novel oral drug formulations. Their potential in modulating adverse effects

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12 December 2020

Mechanisms of acute and chronic intestinal inflammation induced by indomethacin

1 reference

12 December 2020

Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial

1 reference

12 December 2020

Renal effects of COX-2-selective inhibitors

1 reference

12 December 2020

Renal complications of nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation

1 reference

12 December 2020

Importance of local versus systemic effects of non-steroidal anti-inflammatory drugs in increasing small intestinal permeability in man

1 reference

12 December 2020

Nabumetone: a double-blind study in osteoarthrosis

1 reference

12 December 2020

Endothelial dysfunction, hemodynamic forces, and atherogenesis

1 reference

12 December 2020

NSAID induced gastrointestinal complications: the ARAMIS perspective--1997. Arthritis, Rheumatism, and Aging Medical Information System.

1 reference

12 December 2020

Radiochromium (chromium-51) evaluation of gastrointestinal blood loss associated with placebo, aspirin, and nabumetone

1 reference

12 December 2020

A comparative study of nabumetone and indomethacin in ankylosing spondylitis

1 reference

12 December 2020

An overview of the long-term safety experience of nabumetone

1 reference

12 December 2020

Association of nonsteroidal antiinflammatory drugs with upper gastrointestinal disease: epidemiologic and economic considerations

1 reference

12 December 2020

A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis

1 reference

12 December 2020

Nabumetone--a novel anti-inflammatory drug: bioavailability after different dosage regimens

1 reference

12 December 2020

Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib

1 reference

12 December 2020

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1 reference

12 December 2020

Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases

1 reference

12 December 2020

Gastrointestinal safety profile of nabumetone: a meta-analysis

1 reference

12 December 2020

Nonsteroidal antiinflammatory drugs and the gastrointestinal tract. The double-edged sword

1 reference

12 December 2020

Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study

1 reference

12 December 2020

Monitoring the entry of new platelets into the circulation after ingestion of aspirin

1 reference

12 December 2020

A double-blind study of the effect on hemostasis of nabumetone (Relafen) compared to placebo

1 reference

12 December 2020

Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors

1 reference

12 December 2020

Worldwide safety experience with nabumetone

1 reference

12 December 2020

Nabumetone. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases

1 reference

12 December 2020

Effect of 50 mg enteric-coated aspirin (Astrix) on thromboxane and prostacyclin synthesis

1 reference

12 December 2020

Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina

1 reference

12 December 2020

Acute effect of systemic aspirin on gastric mucosa in man

1 reference

12 December 2020

All-cause mortality and vascular events among patients with rheumatoid arthritis, osteoarthritis, or no arthritis in the UK General Practice Research Database.

1 reference

12 December 2020

Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage

1 reference

12 December 2020

Selective cyclooxygenase-2 inhibitors: a pattern of nephrotoxicity similar to traditional nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug therapy and gastric side effects. Does nabumetone provide a solution?

1 reference

12 December 2020

An overview of the clinical pharmacokinetics of nabumetone

1 reference

12 December 2020

COX-1 and COX-2 inhibitors

1 reference

12 December 2020

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

1 reference

12 December 2020

Cyclooxygenase inhibitors and the antiplatelet effects of aspirin

1 reference

12 December 2020

The pathogenesis of coronary artery disease and the acute coronary syndromes (2).

1 reference

12 December 2020

Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drug-related gastrointestinal toxicity: definitions and epidemiology

1 reference

12 December 2020

Effect of nabumetone on hemostasis during arthroscopic knee surgery

1 reference

12 December 2020

Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA.

1 reference

12 December 2020

The renal effects of nonsteroidal anti-inflammatory drugs: summary and recommendations

1 reference

12 December 2020

Safety evaluation of nabumetone in United States clinical trials

1 reference

12 December 2020

Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs

1 reference

12 December 2020

Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing

1 reference

12 December 2020

What have we learned from the large outcomes trials of COX-2 selective inhibitors? The rheumatologist's perspective

1 reference

12 December 2020

A 6-month, double-blind study comparing nabumetone to naproxen in the treatment of osteoarthritis

1 reference

12 December 2020

Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach

1 reference

12 December 2020

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

12 December 2020

Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers

1 reference

12 December 2020

The late induction of prostaglandin G/H synthase-2 in equine preovulatory follicles supports its role as a determinant of the ovulatory process

1 reference

12 December 2020

Nabumetone in the treatment of active adult rheumatoid arthritis.

1 reference

12 December 2020

Gastric ulcer formation and cyclo-oxygenase inhibition in cat antrum follows parenteral administration of aspirin but not salicylate

1 reference

12 December 2020

Comparison of the effects of ketoprofen on platelet function in the presence and absence of aspirin

1 reference

12 December 2020

Evaluation of nabumetone in the treatment of active adult rheumatoid arthritis

1 reference

12 December 2020

An open label study to establish dosing recommendations for nabumetone in juvenile rheumatoid arthritis

1 reference

12 December 2020

Inhibition by corticosteroids of epidermal growth factor-induced recovery of cyclooxygenase after aspirin inactivation

1 reference

12 December 2020

Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat

1 reference

12 December 2020

Gastric Mucosal Lesions Produced by Intravenous Infusion of Aspirin in Cats

1 reference

12 December 2020

Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib

1 reference

12 December 2020

Epidemiology and differential diagnosis of NSAID-induced injury to the mucosa of the small intestine

1 reference

12 December 2020

PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs

1 reference

12 December 2020

Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis

1 reference

12 December 2020

COX-2 is not involved in thromboxane biosynthesis by activated human platelets

1 reference

12 December 2020

Comparative effects of nabumetone, sulindac, and indomethacin on urinary prostaglandin excretion and platelet function in volunteers

1 reference

12 December 2020

Platelet activation in unstable coronary disease

1 reference

12 December 2020

The role of arachidonic acid metabolites in renal homeostasis. Non-steroidal anti-inflammatory drugs renal function and biochemical, histological and clinical effects and drug interactions

1 reference

12 December 2020

Renal hemodynamic effects of nabumetone, sulindac, and placebo in patients with osteoarthritis

1 reference

12 December 2020

Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study

1 reference

12 December 2020

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment

1 reference

12 December 2020

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction

1 reference

12 December 2020

Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial

1 reference

12 December 2020

Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group

1 reference

12 December 2020

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

1 reference

12 December 2020

Clinical pharmacology of platelet cyclooxygenase inhibition

1 reference

12 December 2020

Outcomes studies of the gastrointestinal safety of cyclooxygenase-2 inhibitors

1 reference

12 December 2020

Effects of nabumetone on prostanoid biosynthesis in humans.

1 reference

12 December 2020

Liver insufficiency as a factor modifying the pharmacokinetic characteristic of the preparation nabumetone

1 reference

12 December 2020

Mucosal adaptation to indomethacin induced gastric damage in man--studies on morphology, blood flow, and prostaglandin E2 metabolism

1 reference

12 December 2020

COX-2 and the kidneys

1 reference

12 December 2020

Inhibition of platelet prostaglandin synthetase by oral aspirin

1 reference

12 December 2020

Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions

1 reference

12 December 2020

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

1 reference

12 December 2020

Preclinical overview of nabumetone. Pharmacology, bioavailability, metabolism, and toxicology

1 reference

12 December 2020

Where is the evidence that cyclooxygenase inhibition is the primary cause of nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal injury? Topical injury revisited

1 reference

12 December 2020

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases

1 reference

12 December 2020

Effects of NSAIDs on the kidney

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs and renal response to exercise: a comparison of indomethacin and nabumetone

1 reference

12 December 2020

The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: a review and a hypothesis

1 reference

12 December 2020

Differential effects of aspirin and non-aspirin nonsteroidal antiinflammatory drugs in the primary prevention of myocardial infarction in postmenopausal women

1 reference

12 December 2020

Rational use of analgesic and antiinflammatory drugs

1 reference

12 December 2020

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

1 reference

12 December 2020

Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial

1 reference

12 December 2020

Non-steroidal anti-inflammatory drug induced upper gastrointestinal haemorrhage and bleeding

1 reference

12 December 2020

Expression of the cyclooxygenase-2 gene in gastric epithelium

1 reference

12 December 2020

1 reference

12 December 2020

Clinical acute renal failure with nonsteroidal anti-inflammatory drugs.

1 reference

12 December 2020

Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production

1 reference

12 December 2020

Comparison of the efficacy and safety of naproxen CR and nabumetone in the treatment of patients with osteoarthritis of the knee

1 reference

12 December 2020

The unique pharmacologic profile of nabumetone

1 reference

12 December 2020

Inhibition of eicosanoid biosynthesis by glucocorticoids in humans

1 reference

12 December 2020

Nabumetone therapy of osteoarthritis. A six-week, placebo-controlled study

1 reference

12 December 2020

Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

1 reference

12 December 2020

Nonsteroidal antiinflammatory drug use in patients receiving warfarin: emphasis on nabumetone

1 reference

12 December 2020

Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis

1 reference

12 December 2020

Variability in the risk of major gastrointestinal complications from nonaspirin nonsteroidal anti-inflammatory drugs

1 reference

12 December 2020

A review of gastric ulcer and gastroduodenal injury in normal volunteers receiving aspirin and other non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

A randomized trial comparing wireless capsule endoscopy with push enteroscopy for the detection of small-bowel lesions

1 reference

12 December 2020

Risk of cardiovascular events associated with selective COX-2 inhibitors

1 reference

12 December 2020

Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?

1 reference

12 December 2020

Infection of Helicobacter pylori in gastric adaptation to continued administration of aspirin in humans

1 reference

12 December 2020

Pharmacology of cyclooxygenase-2 inhibition in the kidney

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs (NSAIDs) and the kidney

1 reference

12 December 2020

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids

1 reference

12 December 2020

Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction

1 reference

12 December 2020

Effect of nabumetone (BRL 14777), a new anti-inflammatory drug, on human platelet reactivity ex vivo: comparison with naproxen

1 reference

12 December 2020

Celecoxib-induced acute interstitial nephritis

1 reference

12 December 2020

Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors

1 reference

12 December 2020

COX-1 and COX-2 tissue expression: implications and predictions

1 reference

12 December 2020

Comparison of intravenous and intragastric aspirin in production of antral gastric ulcers in cats

1 reference

12 December 2020

A multicenter study of nabumetone and diclofenac SR in patients with osteoarthritis

1 reference

12 December 2020

Rationalizing cyclooxygenase (COX) inhibition for maximal efficacy and minimal adverse events

1 reference

12 December 2020

Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis.

1 reference

12 December 2020

Intestinal permeability and inflammation in patients on NSAIDs

1 reference

12 December 2020

Rectal administration of nonsteroidal antiinflammatory drugs. Effect on rat gastric ulcerogenicity and prostaglandin E2 synthesis.

1 reference

12 December 2020

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1 reference

12 December 2020

COX2 selective NSAIDs and renal function: gain without pain?

1 reference

12 December 2020

Classical absorption theory and the development of gastric mucosal damage associated with the non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing

1 reference

12 December 2020

The effect of nabumetone and its principal active metabolite on in vitro human gastric mucosal prostanoid synthesis and platelet function

1 reference

12 December 2020

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene

1 reference

12 December 2020

Pathogenesis of peptic ulcer and implications for therapy

1 reference

12 December 2020

Evaluation of flurbiprofen for prevention of reinfarction and reocclusion after successful thrombolysis or angioplasty in acute myocardial infarction. The Flurbiprofen French Trial

1 reference

12 December 2020

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1 reference

12 December 2020

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase

1 reference

12 December 2020

Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists

1 reference

12 December 2020

Long-term treatment of rheumatoid arthritis comparing nabumetone with aspirin

1 reference

12 December 2020

The productive conformation of arachidonic acid bound to prostaglandin synthase

1 reference

12 December 2020

Comparative effects of nabumetone, sulindac, and ibuprofen on renal function.

1 reference

12 December 2020

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

1 reference

12 December 2020

Comparison of the efficacy and safety of nabumetone and diclofenac sodium in the treatment of patients with rheumatoid arthritis

1 reference

12 December 2020

Lack of enterohepatic circulation of the active metabolite of nabumetone in humans

1 reference

12 December 2020

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice

1 reference

12 December 2020

Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production

1 reference

12 December 2020

Comparing analgesic efficacy of non-steroidal anti-inflammatory drugs given by different routes in acute and chronic pain: a qualitative systematic review.

1 reference

12 December 2020

Safe full-dose one-step nabumetone challenge in patients with nonsteroidal anti-inflammatory drug hypersensitivity

1 reference

12 December 2020

Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.

1 reference

12 December 2020

Population pharmacokinetics of the active metabolite of nabumetone in renal dysfunction

1 reference

12 December 2020