(Q28218523)

English

The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine

scientific article (publication date: 7 March 2003)

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scholarly article

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The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine (English)

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author name string

Mika Abu

1

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Timothy R Waters

2

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language of work or name

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publication date

7 March 2003

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Journal of Biological Chemistry

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278

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10

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8739-44

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All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase

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DNA glycosylases in the base excision repair of DNA

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Recent progress in the biology, chemistry and structural biology of DNA glycosylases

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Site specificity of incisions at G:T and O6-methylguanine:T base mismatches in DNA by human cell-free extracts

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21 January 2018

Base analog and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA-glycosylase.

1 reference

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Kinetics of the action of thymine DNA glycosylase

1 reference

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A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch

1 reference

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21 January 2018

3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

1 reference

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21 January 2018

Interaction of the recombinant human methylpurine-DNA glycosylase (MPG protein) with oligodeoxyribonucleotides containing either hypoxanthine or abasic sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

1 reference

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21 January 2018

Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

1 reference

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21 January 2018

Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step

1 reference

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21 January 2018

Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

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Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1.

1 reference

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21 January 2018

Synthesis of 3,N4-etheno, 3,N4-ethano, and 3-(2-hydroxyethyl) derivatives of 2'-deoxycytidine and their incorporation into oligomeric DNA.

1 reference

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21 January 2018

Chromatographic separation of oligodeoxynucleotides with identical length: application to purification of oligomers containing a modified base

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21 January 2018

Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase

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https://api.crossref.org/works/10.1074%2FJBC.M211084200

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Thermodynamics of sequence-specific protein-DNA interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

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Crystal structure of a thwarted mismatch glycosylase DNA repair complex

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https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions

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https://api.crossref.org/works/10.1074%2FJBC.M211084200

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Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases

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21 January 2018

The role of the Escherichia coli mug protein in the removal of uracil and 3,N(4)-ethenocytosine from DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Differential destabilization of the DNA oligonucleotide double helix by a T.G mismatch, 3,N(4)-ethenocytosine, 3,N(4)-ethanocytosine, or an 8-(hydroxymethyl)-3,N(4)-ethenocytosine adduct incorporated into the same sequence contexts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

NMR solution structure of a DNA dodecamer containing single G.T mismatches

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Solution structure of a DNA duplex containing the exocyclic lesion 3,N4-etheno-2'-deoxycytidine opposite 2'-deoxyguanosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

The HAP1 protein stimulates the turnover of human mismatch-specific thymine-DNA-glycosylase to process 3,N(4)-ethenocytosine residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Enhanced activity of adenine-DNA glycosylase (Myh) by apurinic/apyrimidinic endonuclease (Ape1) in mammalian base excision repair of an A/GO mismatch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Thymine DNA glycosylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

1 reference

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Liver-microsome-mediated formation of alkylating agents from vinyl bromide and vinyl chloride

1 reference

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21 January 2018

DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: implications for tolerance to DNA methylation damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Cytotoxic mechanism of 6-thioguanine: hMutSalpha, the human mismatch binding heterodimer, binds to DNA containing S6-methylthioguanine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

Thermodynamics and NMR of internal G.T mismatches in DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211084200

21 January 2018

The impact of an exocyclic cytosine adduct on DNA duplex properties: significant thermodynamic consequences despite modest lesion-induced structural alterations

1 reference

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21 January 2018

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10.1074/JBC.M211084200

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