(Q28238055)

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Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses

scientific article (publication date: July 2006)

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scholarly article

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Genistein-mediated inhibition of glycosaminoglycan synthesis as a basis for gene expression-targeted isoflavone therapy for mucopolysaccharidoses (English)

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Anna Tylki-Szymańska

4

object named as

Anna Tylki-Szymańska

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Alicja Węgrzyn

6

object named as

Alicja Wegrzyn

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Grzegorz Węgrzyn

7

object named as

Grzegorz Wegrzyn

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Joanna Jakóbkiewicz-Banecka

2

object named as

Joanna Jakóbkiewicz-Banecka

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Sylwia Barańska

3

object named as

Sylwia Barańska

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author name string

Ewa Piotrowska

1

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Barbara Czartoryska

5

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language of work or name

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publication date

July 2006

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European Journal of Human Genetics

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14

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7

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846-52

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Structural insights into biological roles of protein-glycosaminoglycan interactions

1 reference

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A general model for genetic regulation of turnover of glycosaminoglycans suggests a possible procedure for prediction of severity and clinical progress of mucopolysaccharidoses

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Enzyme-replacement therapy in mucopolysaccharidosis I.

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Enzyme replacement therapy for mucopolysaccharidosis I: a randomized, double-blinded, placebo-controlled, multinational study of recombinant human alpha-L-iduronidase (laronidase).

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The first 5 years of clinical experience with laronidase enzyme replacement therapy for mucopolysaccharidosis I.

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Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome).

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Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.

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Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression.

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A role for the interleukin-1 receptor in the pathway linking static mechanical compression to decreased proteoglycan synthesis in surface articular cartilage

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Isolation and characterization of the proteoglycans synthesized by adult human pulp fibroblasts in vitro

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Improved and simple micro assay for sulfated glycosaminoglycans quantification in biological extracts and its use in skin and muscle tissue studies

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Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

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Epidermal growth factor potentiates the induction of ornithine decarboxylase activity by prostaglandins in embryonic palate mesenchymal cells: effects on cell proliferation and glycosaminoglycan synthesis.

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Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone (or epidermal growth factor) and a soluble oocyte factor (or transforming growth factor beta1).

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Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways

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Proteoglycan synthesis induced by transforming and basic fibroblast growth factors in human malignant mesothelioma is mediated through specific receptors and the tyrosine kinase intracellular pathway.

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Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit chondrocytes at concentrations inducing cartilage lesions in vivo

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Changes in hair morphology of mucopolysaccharidosis I patients treated with recombinant human alpha-L-iduronidase (laronidase, Aldurazyme)

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Atypical microbial infections of digestive tract may contribute to diarrhea in mucopolysaccharidosis patients: a MPS I case study

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Concurrent measurement of unbound genistein in the blood, brain and bile of anesthetized rats using microdialysis and its pharmacokinetic application

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Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I

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Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.

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Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women

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Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men

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Subchronic and chronic safety studies with genistein in dogs

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Safety, tolerability, and pharmacokinetics of single ascending doses of synthetic genistein (Bonistein) in healthy volunteers

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Clinical characteristics and pharmacokinetics of purified soy isoflavones: multiple-dose administration to men with prostate neoplasia

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Soy isoflavones--phytoestrogens and what else?

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Soy protein formulas in children: no hormonal effects in long-term feeding

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Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants

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Genetic toxicity studies with genistein

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