Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q28239790)
Watch
English
PTEN is a protein tyrosine phosphatase for IRS1
scientific article (publication date: June 2014)
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
title
PTEN is a protein tyrosine phosphatase for IRS1
(English)
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
main subject
structural biology
0 references
author
Yuji Shi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Justin R. Cross
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Craig B. Thompson
series ordinal
5
object named as
Craig Thompson
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
author name string
Junru Wang
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Sarat Chandarlapaty
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Neal Rosen
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Xuejun Jiang
series ordinal
7
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
language of work or name
English
0 references
publication date
11 May 2014
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
published in
Nature Structural & Molecular Biology
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
volume
21
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
issue
6
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
page(s)
522-527
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
cites work
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
E3 ligase Nedd4 promotes axon branching by downregulating PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Rak functions as a tumor suppressor by regulating PTEN protein stability and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Nedd4 controls animal growth by regulating IGF-1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Ubiquitination regulates PTEN nuclear import and tumor suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
20 March 2017
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
7 April 2017
The functions and regulation of the PTEN tumour suppressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
7 April 2017
Critical nodes in signalling pathways: insights into insulin action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
7 April 2017
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
7 April 2017
E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Spatial regulation of receptor tyrosine kinases in development and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Functional analysis of the protein phosphatase activity of PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
The role of PTEN signaling perturbations in cancer and in targeted therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Post-translational regulation of PTEN.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
PTEN and Cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
29 September 2017
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.2828
retrieved
21 January 2018
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.2828
retrieved
21 January 2018
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNSMB.2828
retrieved
21 January 2018
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
27 November 2018
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4167033
retrieved
27 November 2018
Identifiers
DOI
10.1038/NSMB.2828
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
PMCID
4167033
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
PubMed ID
24814346
1 reference
stated in
Europe PubMed Central
PMCID
4167033
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24814346%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 March 2020
Springer Nature article ID
10.1038/nsmb.2828
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
