(Q28244016)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785412%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion (English)

1 reference

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8 February 2020

0 references

Shyam S. Krishnakumar

1

1 reference

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8 February 2020

Frédéric Pincet

10

1 reference

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8 February 2020

11

James E Rothman

1 reference

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8 February 2020

author name string

Daniel T Radoff

2

1 reference

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8 February 2020

Daniel Kümmel

3

1 reference

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8 February 2020

Claudio G Giraudo

4

1 reference

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8 February 2020

Feng Li

5

1 reference

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8 February 2020

Lavan Khandan

6

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8 February 2020

Stephanie Wood Baguley

7

1 reference

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8 February 2020

Jeff Coleman

8

1 reference

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8 February 2020

Karin M Reinisch

9

1 reference

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8 February 2020

language of work or name

English

0 references

publication date

24 July 2011

1 reference

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Nature Structural & Molecular Biology

8 February 2020

published in

1 reference

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8 February 2020

volume

18

1 reference

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8 February 2020

issue

8

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8 February 2020

page(s)

934-940

1 reference

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Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

8 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Complexin controls the force transfer from SNARE complexes to membranes in fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Alternative zippering as an on-off switch for SNARE-mediated fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Membrane fusion: grappling with SNARE and SM proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

X-ray structure of a neuronal complexin-SNARE complex from squid

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Three-dimensional structure of the complexin/SNARE complex

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Synaptotagmin I functions as a calcium regulator of release probability

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

SNAREpins: minimal machinery for membrane fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

SNAP receptors implicated in vesicle targeting and fusion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Complexins: cytosolic proteins that regulate SNAP receptor function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Protein determinants of SNARE-mediated lipid mixing

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

A fast, single-vesicle fusion assay mimics physiological SNARE requirements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Complexin and Ca2+ stimulate SNARE-mediated membrane fusion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

A clamping mechanism involved in SNARE-dependent exocytosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Fusion of cells by flipped SNAREs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Probing the relation between force--lifetime--and chemistry in single molecular bonds

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Complexins regulate a late step in Ca2+-dependent neurotransmitter release

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Timing of neurotransmission at fast synapses in the mammalian brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

The Ca2+ affinity of synaptotagmin 1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol 4,5-bisphosphate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668341

A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

2 June 2018

1 reference

Distinct domains of complexin I differentially regulate neurotransmitter release

21 January 2018

1 reference

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

21 January 2018

1 reference

Direct interaction of a Ca2+-binding loop of synaptotagmin with lipid bilayers.

21 January 2018

1 reference

Membrane curvature in synaptic vesicle fusion and beyond.

21 January 2018

1 reference

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

21 January 2018

1 reference

Complexin cross-links prefusion SNAREs into a zigzag array

31 March 2020

1 reference

Activity-dependent changes in partial VAMP complexes during neurotransmitter release

31 March 2020

1 reference

Liposome fusion assay to monitor intracellular membrane fusion machines

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2103

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785412%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21785412%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

21785412

2 references