(Q28254889)

1

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Yahong Wang

2

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Ling-Yang Hao

3

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Xikui Liu

4

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Chuck A Lesch

5

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Brian M Sanchez

6

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Jay M Wendling

7

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Rodney W Morgan

8

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Tom D Aicher

9

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Laura L Carter

10

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Peter L Toogood

11

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Gary D Glick

Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets

12

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language of work or name

English

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publication date

February 2015

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published in

Nature Chemical Biology

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volume

11

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issue

2

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page(s)

141-7

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cites work

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

A validated regulatory network for Th17 cell specification

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/NCHEMBIO.1714

IL-17 family cytokines and the expanding diversity of effector T cell lineages

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Development, cytokine profile and function of human interleukin 17-producing helper T cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Metabolic checkpoints in activated T cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

A complex issue on CD4(+) T-cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

T(H)17 cells in tumour immunity and immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Dynamic regulatory network controlling TH17 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Sterols and oxysterols in immune cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

LXR signaling couples sterol metabolism to proliferation in the acquired immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Control of TH17 cells occurs in the small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Cellular cholesterol trafficking and compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Hypercholesterolemia and risk of incident psoriasis and psoriatic arthritis in US women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Innate IL-17-producing cells: the sentinels of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Cholesterol sulfate induces expression of the skin barrier protein filaggrin in normal human epidermal keratinocytes through induction of RORα.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1714

Therapeutic potential of targeting IL-17

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25558972

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxysterols and atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25558972

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1714

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25558972

1 reference

Consolidated OpenCitations Corpus – April 2017