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Structural basis of integrin-mediated signal transduction
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scholarly article
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review article
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Europe PubMed Central
title
Structural basis of integrin-mediated signal transduction
(English)
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author
Yoshikazu Takada
series ordinal
1
object named as
Y Takada
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author name string
T Kamata
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2
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A Irie
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3
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W Puzon-McLaughlin
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4
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X P Zhang
series ordinal
5
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language of work or name
English
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publication date
October 1997
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published in
Matrix Biology
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volume
16
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issue
4
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page(s)
143-51
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cites work
Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium
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Binding of glycoprotein IIIa-derived peptide 217-231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex
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Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor
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A discrete sequence in a platelet integrin is involved in ligand recognition
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Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding
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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
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Contributions of the I and EF hand domains to the divalent cation-dependent collagen binding activity of the alpha2beta1 integrin
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Identifying the putative metal ion-dependent adhesion site in the beta2 (CD18) subunit required for alphaLbeta2 and alphaMbeta2 ligand interactions
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VLA proteins in the integrin family: structures, functions, and their role on leukocytes
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Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit
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A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts
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Integrins: versatility, modulation, and signaling in cell adhesion
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Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits.
1 reference
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Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).
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Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)
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A novel LFA-1 activation epitope maps to the I domain
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inferred from DOI database lookup
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation
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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain
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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
1 reference
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Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.
1 reference
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Integrin function: molecular hierarchies of cytoskeletal and signaling molecules
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The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy
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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies
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A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins
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Crossref
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Critical residues for ligand binding in an I domain-like structure of the integrin beta1 subunit.
1 reference
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Crossref
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Regulation of conformation and ligand binding function of integrin alpha5beta1 by the beta1 cytoplasmic domain
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The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF.
1 reference
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Crossref
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Integrins
1 reference
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Crossref
reference URL
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Molecular mapping of functional antibody binding sites of alpha 4 integrin
1 reference
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Crossref
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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
1 reference
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A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques
1 reference
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Crossref
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1 reference
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Crossref
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Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit
1 reference
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Crossref
reference URL
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1 reference
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Crossref
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A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.
1 reference
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Crossref
reference URL
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inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
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inferred from DOI database lookup
Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Identifiers
DOI
10.1016/S0945-053X(97)90002-0
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PubMed publication ID
9402003
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