(Q28258853)

5

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author name string

Neil R Williamson

1

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Tamzin Gristwood

3

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Suresh R Chawrai

4

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George P C Salmond

The biosynthesis and regulation of bacterial prodiginines

6

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language of work or name

English

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publication date

December 2007

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published in

Future Microbiology

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volume

2

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issue

6

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page(s)

605-18

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cites work

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Seeing red: The story of prodigiosin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Serratia marcescens: historical perspective and clinical review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Tumours and Coley's toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The prodigiosins, proapoptotic drugs with anticancer properties

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

An endotoxin-induced serum factor that causes necrosis of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin-Like Pigments

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Chemistry and biology of roseophilin and the prodigiosin alkaloids: a survey of the last 2500 years

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The use of functional genomics for the identification of a gene cluster encoding for the biosynthesis of an antifungal tambjamine in the marine bacterium Pseudoalteromonas tunicata

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Biological formation of pyrroles: nature's logic and enzymatic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

New immunosuppressive drugs: mechanistic insights and potential therapeutic advances

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Selective immunosuppression of prodigiosin 25-C and FK506 in the murine immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Effective prevention of lethal acute graft-versus-host disease by combined immunosuppressive therapy with prodigiosin and cyclosporine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin from the supernatant of Serratia marcescens induces apoptosis in haematopoietic cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin-induced apoptosis in human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Synthesis and anti-cancer activity of C-ring-functionalized prodigiosin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Synthesis, proton-affinity and anti-cancer properties of the prodigiosin-group natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Antimetastatic effect of prodigiosin through inhibition of tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

High cytotoxic sensitivity of the human small cell lung doxorubicin-resistant carcinoma (GLC4/ADR) cell line to prodigiosin through apoptosis activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Two distinct pathways leading to nuclear apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin induces apoptosis by acting on mitochondria in human lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin induces caspase-9 and caspase-8 activation and cytochrome C release in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Cycloprodigiosin hydrochloride, H(+)/CL(-) symporter, induces apoptosis and differentiation in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Cycloprodigiosin hydrocloride suppresses tumor necrosis factor (TNF) alpha-induced transcriptional activation by NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The cytotoxic prodigiosin induces phosphorylation of p38-MAPK but not of SAPK/JNK.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Activation of protein kinase C for protection of cells against apoptosis induced by the immunosuppressor prodigiosin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosins as a new group of H+/Cl- symporters that uncouple proton translocators

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin 25-C uncouples vacuolar type H(+)-ATPase, inhibits vacuolar acidification and affects glycoprotein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl- symport

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Amidopyrroles: from anion receptors to membrane transport agents

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Co-transport of H+/Cl- by a synthetic prodigiosin mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Synthesis and biological evaluation of nonylprodigiosin and macrocyclic prodigiosin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Synthesis, anion-binding properties, and in vitro anticancer activity of prodigiosin analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Prodigiosin is a chloride carrier that can function as an anion exchanger

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Non-apoptotic concentrations of prodigiosin (H+/Cl- symporter) inhibit the acidification of lysosomes and induce cell cycle blockage in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Copper-nuclease efficiency correlates with cytotoxicity for the 4-methoxypyrrolic natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Influence of the a-ring on the redox and nuclease properties of the prodigiosins: importance of the bipyrrole moiety in oxidative DNA cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Studies on DNA cleavage by cytotoxic pyrrole alkaloids reveal the distinctly different behavior of roseophilin and prodigiosin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Zinc and copper complexes of prodigiosin: implications for copper-mediated double-strand DNA cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

DNA interaction and dual topoisomerase I and II inhibition properties of the anti-tumor drug prodigiosin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Indoloprodigiosins from the C-10 bipyrrolic precursor: new antiproliferative prodigiosin analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The retinoblastoma protein: more than a tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The NF-kappaB regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The NF-kappa B and I kappa B proteins: new discoveries and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Jaks and STATs: biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Mutasynthesis - uniting chemistry and genetics for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

BCL2 family in DNA damage and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Apoptosis-targeted therapies for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Potent in vitro anticancer activity of metacycloprodigiosin and undecylprodigiosin from a sponge-derived actinomycete Saccharopolyspora sp. nov.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Identification of a red-pigmented bacterium producing a potent anti-tumor N-alkylated prodigiosin as Serratia marcescens

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F17460913.2.6.605

Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.38.128

Identifiers

DOI

10.2217/17460913.2.6.605

1 reference

Consolidated OpenCitations Corpus – April 2017

3596545

3596545

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference