(Q28264722)

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Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

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Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? (English)

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Johannes Hebebrand

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object named as

J Hebebrand

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Helmut Remschmidt

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object named as

H Remschmidt

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13

object named as

V M Steen

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author name string

S Le Hellard

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F M Theisen

2

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M Haberhausen

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M B Raeder

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J Fernø

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S Gebhardt

6

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A Hinney

7

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J C Krieg

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C Mehler-Wex

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M M Nöthen

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language of work or name

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publication date

March 2009

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Molecular Psychiatry

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14

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3

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308-17

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From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

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https://api.crossref.org/works/10.1038/SJ.MP.4002133

21 April 2017

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002133

21 April 2017

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002133

21 April 2017

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002133

21 April 2017

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

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https://api.crossref.org/works/10.1038/SJ.MP.4002133

21 April 2017

Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

The effects of antipsychotic therapy on serum lipids: a comprehensive review.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Physical health monitoring of patients with schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Rsearch Database

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Clozapine-induced weight gain: a study in monozygotic twins and same-sex sib pairs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Genetics of antipsychotic treatment emergent weight gain in schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Susceptibility genes for the side effect of antipsychotics on body weight and obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Polymorphism of the promoter region of the serotonin 5-HT(2C) receptor gene and clozapine-induced weight gain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

-759 C/T polymorphism of 5-HT2C receptor gene and early phase weight gain associated with antipsychotic drug treatment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Regulation of gene expression by SREBP and SCAP.

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https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Mechanisms of regulation of gene expression by fatty acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

A common genetic variant is associated with adult and childhood obesity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Prevalence of obesity in adolescent and young adult patients with and without schizophrenia and in relationship to antipsychotic medication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Lack of association between rs7566605 and obesity in a Chinese population

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

Serum leptin levels increase rapidly after initiation of clozapine therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

21 January 2018

A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevalence of the metabolic syndrome among patients receiving clozapine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

Association of initial antipsychotic response to clozapine and long-term weight gain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002133

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.MP.4002133

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10.1038/sj.mp.4002133

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