(Q28265138)

12 December 2020

Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin

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12 December 2020

PTEN function: how normal cells control it and tumour cells lose it

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12 December 2020

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

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12 December 2020

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

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12 December 2020

The yeast Tsa1 peroxiredoxin is a ribosome-associated antioxidant

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12 December 2020

Peroxisomes and oxidative stress

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12 December 2020

Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte

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12 December 2020

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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12 December 2020

Glutathione is recruited into the nucleus in early phases of cell proliferation.

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12 December 2020

The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2.

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12 December 2020

Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1

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12 December 2020

Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins

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12 December 2020

Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

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12 December 2020

Reversible inactivation of the tumor suppressor PTEN by H2O2

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12 December 2020

Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling

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12 December 2020

Thioredoxin-dependent peroxide reductase from yeast

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12 December 2020

Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.

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12 December 2020

Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice.

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12 December 2020

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

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12 December 2020

Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress

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12 December 2020

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution

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12 December 2020

Typical 2-Cys peroxiredoxins--modulation by covalent transformations and noncovalent interactions.

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12 December 2020

Glutathione peroxidases and redox-regulated transcription factors

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12 December 2020

Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression

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12 December 2020

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

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12 December 2020

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

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12 December 2020

Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid

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12 December 2020

Peroxiredoxins, oxidative stress, and cell proliferation.

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12 December 2020

Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine

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12 December 2020

Structure, mechanism and regulation of peroxiredoxins

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12 December 2020

Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress

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12 December 2020

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

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12 December 2020

Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification

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12 December 2020

A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins

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12 December 2020

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

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12 December 2020

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice

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12 December 2020

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice

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12 December 2020

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.

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12 December 2020

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

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12 December 2020

Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells

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12 December 2020

The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation.

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12 December 2020

Catalase activity is regulated by c-Abl and Arg in the oxidative stress response

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12 December 2020

The oligomeric conformation of peroxiredoxins links redox state to function.

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12 December 2020

Redox regulation of the Cdc25 phosphatases

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12 December 2020

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

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12 December 2020

Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity

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12 December 2020

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

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12 December 2020

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

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12 December 2020

Cellular and subcellular localization of catalase in the heart of transgenic mice

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12 December 2020

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

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12 December 2020

Cell signaling. H2O2, a necessary evil for cell signaling

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12 December 2020

Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance

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12 December 2020

Glutathione peroxidase 1 is regulated by the c-Abl and Arg tyrosine kinases

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12 December 2020

Electrostatic evaluation of the signature motif (H/V)CX5R(S/T) in protein-tyrosine phosphatases.

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12 December 2020

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

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12 December 2020

The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress

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12 December 2020

Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.

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12 December 2020

Mammalian catalase: a venerable enzyme with new mysteries

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12 December 2020

Oxidation and nuclear localization of thioredoxin-1 in sparse cell cultures

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12 December 2020

Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation

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12 December 2020

Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases

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12 December 2020

Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress

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12 December 2020

Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.

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12 December 2020

Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.

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12 December 2020

Low catalase activity in xeroderma pigmentosum fibroblasts and SV40-transformed human cell lines is directly related to decreased intracellular levels of the cofactor, NADPH.

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12 December 2020

Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery

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12 December 2020

Protein-sulfenic acids: diverse roles for an unlikely player in enzyme catalysis and redox regulation

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12 December 2020

Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex.

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12 December 2020

Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.

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12 December 2020

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

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12 December 2020

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

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12 December 2020

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

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12 December 2020

Peroxiredoxin 1 interacts with androgen receptor and enhances its transactivation

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12 December 2020

Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia

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12 December 2020

Heat shock inactivates cellular antioxidant defenses against hydrogen peroxide: protection by glucose

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12 December 2020

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

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12 December 2020

Tumor spectrum, tumor latency and tumor incidence of the Pten-deficient mice

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12 December 2020