(Q28267813)

27 March 2017

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Christopher J Fowler

1

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Christopher J. Fowler

series ordinal

1

1 reference

27 March 2017

language of work or name

English

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publication date

2015

1 reference

Handbook of experimental pharmacology

27 March 2017

published in

1 reference

27 March 2017

volume

231

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page(s)

95-128

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

27 March 2017

cites work

1 reference

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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain

31 March 2020

1 reference

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COX-2-derived endocannabinoid metabolites as novel inflammatory mediators.

31 March 2020

1 reference

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Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

31 March 2020

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Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.

31 March 2020

1 reference

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New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis

31 March 2020

1 reference

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Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test

31 March 2020

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Endocannabinoids control spasticity in a multiple sclerosis model

31 March 2020

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Sex differences in pain: a brief review of clinical and experimental findings

31 March 2020

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Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice

31 March 2020

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Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.

31 March 2020

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Reassessment of the role of cannabinoids in the management of pain

31 March 2020

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Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs

31 March 2020

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A new strategy to block tumor growth by inhibiting endocannabinoid inactivation

31 March 2020

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R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids

31 March 2020

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Anandamide deficiency and heightened neuropathic pain in aged mice.

31 March 2020

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Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol

31 March 2020

1 reference

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Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo

31 March 2020

1 reference

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A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

31 March 2020

1 reference

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The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

31 March 2020

1 reference

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Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

31 March 2020

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Deficits in spontaneous burrowing behavior in the rat bilateral monosodium iodoacetate model of osteoarthritis: an objective measure of pain-related behavior and analgesic efficacy.

31 March 2020

1 reference

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Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase controls mouse intestinal motility in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

31 March 2020

1 reference

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Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Functional disassociation of the central and peripheral fatty acid amide signaling systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Targeting the endocannabinoid system: to enhance or reduce?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Challenges in the search for drugs to treat central nervous system disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Monoacylglycerol lipase - a target for drug development?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

NSAIDs: eNdocannabinoid stimulating anti-inflammatory drugs?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Selective inhibition of anandamide cellular uptake versus enzymatic hydrolysis--a difficult issue to handle

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Spinal cord FAAH in normal micturition control and bladder overactivity in awake rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The fatty acid amide hydrolase inhibitor oleoyl ethyl amide counteracts bladder overactivity in female rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

A role for endocannabinoids in indomethacin-induced spinal antinociception

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics follo

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

An endocannabinoid mechanism for stress-induced analgesia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Estimation of acute flurbiprofen and ketoprofen toxicity in rat gastric mucosa at therapy-relevant doses

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid-binding proteins transport N-acylethanolamines to nuclear receptors and are targets of endocannabinoid transport inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Modulation of anxiety through blockade of anandamide hydrolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

A decrease in anandamide signaling contributes to the maintenance of cutaneous mechanical hyperalgesia in a model of bone cancer pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of endocannabinoid degradation in experimental endotoxemia reduces leukocyte adhesion and improves capillary perfusion in the gut

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Can the pharmaceutical industry reduce attrition rates?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide].

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Role of FAAH-like anandamide transporter in anandamide inactivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Peripheral and spinal activation of cannabinoid receptors by joint mobilization alleviates postoperative pain in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The endogenous cannabinoid system protects against colonic inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Effects of alterations in cannabinoid signaling, alone and in combination with morphine, on pain-elicited and pain-suppressed behavior in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus)

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

DAGL-dependent endocannabinoid signalling: roles in axonal pathfinding, synaptic plasticity and adult neurogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid amide hydrolase inhibition enhances the anti-allodynic actions of endocannabinoids in a model of acute pain adapted for the mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

"Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shell stimulates food intake and increases c-Fos expression in the hypothalamus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Effects of COX-2 inhibition on spinal nociception: the role of endocannabinoids

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Non-psychotropic analgesic drugs from the endocannabinoid system: "magic bullet" or "multiple-target" strategies?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

How were new medicines discovered?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Pain modulation by release of the endogenous cannabinoid anandamide

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

An industry perspective on the role and utility of animal models of pain in drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Long-term consequences of perinatal fatty acid amino hydrolase inhibition.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4

Fatty acid-binding protein 5 (FABP5) regulates cognitive function both by decreasing anandamide levels and by activating the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-20825-1_4